摘要
目的探讨甲苯二异氰酸酯(toluene diisocyanate,TDI)作业工人的肺功能及血清特异性IgE抗体(SIgE)的改变。方法收集某化工厂TDI作业工人76名作为观察组,并选取该工厂管理人员33名作为对照组。分别测定用力肺活量(forced vital capacity,FVC)、第1秒用力呼气量(forced expiratory volume in 1 second,FEV1)、第1秒用力呼气量占FVC的百分比(FEV1/FVC)、最大呼气峰流速值(peak expiratory flow,PEF)以及血清特异性IgE(S-IgE)、总IgE。结果 TDI作业工人FVC%pred、FEV1%pred、FEV1/FVC较对照组有所下降,观察组的PEF下降值明显高于对照组(P<0.05)。工龄>8年组与工龄≤8年组工人的肺功能亦出现下降,其中FVC%pred、FEV1/FVC差异有统计学意义(P<0.05)。与S-IgE阴性作业工人相比,S-IgE阳性作业工人FVC%pred、FEV1%pred、FEV1/FVC降低(P<0.05),PEF下降值更为明显(P<0.05)。结论长期低浓度接触TDI,可引起肺功能下降。S-IgE阳性工人更易存在气道高反应性,肺功能受损更为严重。
Objective To investigate the pulmonary function and serum S-IgE levels in workers exposed to toluene diisocyanate （TDI）. Methods Seventy six TDI-exposed workers （observation group） and 33 managerial staff （control group） from a chemical plant were included in the study. The pulmonary function tests （FVC, FEV1, FEV1/FVC and PEF） were performed and serum S-IgE, total IgE were measured. Results Compared with the control group, the pulmonary function was declined of the workers exposed to TDI. And the decline ratio on PEF of observation group was significantly higher than that of control group. Pulmonary function （FVC% pred, FEV1/FVC） were also decreased in workers with 〉 8 working years compared to those 〈 8 working years （ P 〈 0.05 ）. The pulmonary function of S-lgE positive workers was significantly lower than that of S-lgE negative workers （P 〈0. 05 ）. The decline ratio on PEF in S-lgE positive group was more marked than that in S-lgE negative ones （P 〈 0.05 ）. Conclusion Long-term exposure to TDI may cause pulmonary function decline. Workers with positive S-lgE are more likely to have the airway hyperresponsiveness, so that their lung function would be impaired more seriously.
出处
《同济大学学报（医学版）》
CAS
2014年第1期90-93,共4页
Journal of Tongji University(Medical Science)
