摘要
目的探讨儿童代谢综合征(MS)与颈动脉超声参数和血液生化指标的相关性。方法将30例儿童代谢综合征患者作为MS组,30例儿童单纯性肥胖者作为肥胖非MS组,随机选择30例健康体检儿童作为正常对照组,测量所有入选儿童身高、体重、腰围、臀围、收缩压、舒张压、空腹血糖、空腹胰岛素、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白,计算体质量指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR)和动脉粥样硬化指数(AI);采用彩色多普勒超声仪观察各组儿童颈动脉内径(CADIA)、颈动脉内膜-中层厚度(CAIMT);比较MS组、肥胖非MS组和正常对照组各项指标。结果与正常对照组比较,MS组空腹血糖、空腹胰岛素、HOMA-IR、总胆固醇、甘油三酯、低密度脂蛋白升高,高密度脂蛋白降低,其中空腹血糖、空腹胰岛素、HOMA-IR、甘油三酯、高密度脂蛋白、低密度脂蛋白指标差异具有统计学意义(P<0.01或P<0.05);MS组与肥胖非MS组比较R-CAIMT、L-CAIMT增厚,差异具有统计学意义(P<0.01),R-CADIA、L-CADIA比较差异无统计学意义(P>0.05)。结论颈动脉超声参数和血液生化指标能提示MS儿童存在血管内皮功能损害,为MS儿童心血管病变的早期发现和治疗提供客观依据。
Objective To investigate the association of ultrasound measurements of carotid artery and blood biochemical tests in children with metabolic syndrome（MS）. Methods The study comprised 30 MS children, 30 obese children with non-MS and 30 normal weight children（control group）. All participants underwent physical examination, ultrasound measurement of carotid artery and biochemical tests including systolic blood pressure（SBP）, diastolic blood pressure（DBP）, fasting plasma glucose（FPG）, fasting insulin（FINS）, total cholesterol（TC）, triglycerides（TG）, low density lipoprotein（LDL）, high density lipoprotein（HDL）, then compared each index in each group. Results Compared with control group, FBG, FIN, HOMA-IR, TC, TG and LDL were higher, HDL was lower in MS group, and the difference in FBG, FIN, HOMA-IR, TG, HDL and LDL were significantly. The R-CAIMT, L-CAIMT in MS group were significant higher than in control group（P＆lt;0.01）. Conclusion Ultrasound measurements of carotid artery and blood biochemical tests could prompt endothelial function damage and provide objective bases for detecting and treating cardiovascular early in MS children.
出处
《中华临床医师杂志（电子版）》
CAS
2013年第23期145-148,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
天津医科大学科研基金(2010KY24)
关键词
儿童
超声检查
代谢综合征
颈动脉内膜-中层厚度
血液生化指标
Child
Ultrasonography
Metabolic syndrome
Carotid artery intima-media thickness
Blood biochemical tests
