摘要
目的探讨匹多莫德联合布地奈德气雾剂治疗儿童支气管哮喘的疗效及安全性。方法选取2011年6月至2012年9月于绵阳市中心医院儿科门诊治疗的200例支气管哮喘患儿为研究对象,根据治疗方法不同,将其分为观察组(n=100,匹多莫德+布地奈德气雾剂)和对照组(n=100,仅用布地奈德气雾剂)。两组患儿的性别、平均年龄、病程及病情严重程度分级等基础资料比较,差异无统计学意义(P>0.05)(本研究遵循的程序符合绵阳市中心医院人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得受试患儿监护人的知情同意,并与之签署临床研究知情同意书)。比较两组患儿的疗效、哮喘发作次数、发作持续时间等。结果观察组的总有效率明显高于对照组(95.00%vs.74.00%,P<0.01)。观察组的哮喘发作持续时间[(4.00±1.32)d vs.(6.78±1.58)d,P<0.05]以及发作程度(P<0.01)均明显短于对照组。结论匹多莫德联合布地奈德气雾剂治疗儿童支气管哮喘疗效更佳。
Objective To investigate the efficacy and safety of pidotimod combined with budesonide aerosol in the treatment of bronchial asthma in children. Methods Selected 200 cases children with asthma treated in hospital outpatient from June 2011 to September 2012 as research subjects. They were randomly divided into observation group （n = 100, budesonide aerosol ＋ pidotimod） and control group （n =100, budesonide aerosol） according to the different therapeutic methods. Comparison of the two groups of gender, average age, duration and severity grading and other basic information on aspects of children, the differences were not statistically significant （P〉0.05）. In this study, the procedure followed in line with ethical standards established by Institutional Review Board of the Central Hospital of Mianyang, approved by the Commission, grouping the consent of the guardian of the children tested, and with the signing of informed consent in clinical research. The following information were compared between two groups, the number of asthma attacks, attack duration and extent of attack. Results The efficient of observation group was significantly higher than that in control group（95.00% vs. 74.00% ,P〈0. 01）. The number of asthma attacks, attack duration [（4.00±1.32） d vs. （6.78±1.58） d,P〈0.051 and extent of attack（P〈0.01） were significantly shorter than those of control group. Conclusions Pidotimod combined with budesonide aerosol in the treatment of bronchial asthma in children is better than budesonide only.
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2013年第6期687-690,共4页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
