摘要
目的探讨GLP-1与代谢综合征各项指标之间的关系。方法测定静脉血空腹血糖(FBG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白(LDL-C)、甘油三酯(TG)、总胆固醇(TC)等指标,同时测量血压、身高、体重、腰臀比,计算体质指数(BMI,体重/身高2)。应用ELISA方法检测受试者血GLP-1水平。结果随代谢分数的增加,血GLP-1水平显著升高,且GLP-1含量与血脂有密切关系,与空腹血糖等无明显联系。结论循环血GLP-1含量的升高是并发心血管疾病的危险因素。
Objective： Detecting the circulating levels of glucagons-like peptide-1 of high risk patients to examine relationships between the metabolic syndrome and glucagons-like peptide-1. Methods： We measured MS risk factors and measured blood pressure, weight, body mass index and so on. Serum GLP-1 were measured by ELISA. Results： The levels of Serum GLP -1 were significantly increased correlated with the accumulation of MetS risk factors components, There was a significant interaction between circulating GLP-1, serum high-density lipoprotein cholesterol, triglyceride, and cyctatin C , but not fasting glucose or presence of diabetes. Conclusion： Circulating levels of GLP-1 in relation to the accumulation in MetS factors suggested that MetS patients with elevated levels of GLP-1 are high-risk patients for cardiovascular disease.
出处
《泰山医学院学报》
CAS
2013年第12期912-914,共3页
Journal of Taishan Medical College
关键词
代谢综合征
GLP-1
心血管疾病
the metabolic syndrome
glucagons-like peptide-1
cardiovascular disease
