摘要
目的评价多烯磷脂酰胆碱联合还原型谷胱甘肽治疗慢性乙型肝炎肝纤维化的疗效。方法 120例慢性乙型肝炎肝纤维化患者随机分为两组:治疗组应用多烯磷脂酰胆碱465 mg+还原型谷胱甘肽1.8 g静滴1次/天;对照组应用苦参素0.6 g静滴1次/天,两组疗程均为8周。观察用药前后血清肝纤维化(HA、LN、PC-Ⅲ、Ⅳ-C)的变化。结果治疗后两组患者血清肝纤维化各项指标均明显改善(P<0.05),与对照组比较差异有统计学意义(P<0.05)。结论多烯磷脂酰胆碱联合还原型谷胱甘肽有明显改善肝脏纤维化作用。
Objective ： To investigate the clinical efficacy of combination treatment of polyene phosphatidylcholine com- bined with reduced glutathione in patients with hepatic fibrosis caused by hepatitis B. Methods ： One hundred and twenty pa- tients with hepatic fibrosis of hepatitis B virus infection were randomly divided into two groups. The treatment group （ 60 pa- tients） was given polyene phosphatidylcholine 465mg daily,reduced glutathione 1.8g daily by intravenous for 8 weeks;the control group （ 60 patients） was given oxymatrine O. 6g daily by intravenous for 8 weeks ; The serum hyaluronic acid （ HA）, serum procollagen typeIII （ PC-III）, laminin （LN） and IVcollagen （ IV-C ） were observed. Results： The serum fibrosis markers were decreased in two groups after treatment（ P 〈0. 05） ,and the treatment group decreased significantly compared with control group（ P 〈 0. 05 ）. Conclusion：Polyenc phosphatidylcholine and reduced glutathione Can effectively reduce the level of hepatic fibrosismarks in chronic hepatitis B patients.
出处
《泰山医学院学报》
CAS
2013年第11期847-849,共3页
Journal of Taishan Medical College
