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0.25%盐酸罗哌卡因腹腔注射对小白鼠宫缩痛的影响

Effects of 0.25% ropivacaine intraperitoneal injection on the pains of uterine contractionin mice
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摘要 目的探讨盐酸罗哌卡因腹腔注射对小白鼠宫缩痛的镇痛作用,探索分娩镇痛的安全有效新途径。方法 60只雌性小白鼠随机分成三组,Ⅰ组:生理盐水(0.9%氯化钠水溶液)对照组(n=20),Ⅱ组:催产素+生理盐水(0.9%氯化钠水溶液)组(n=20),Ⅲ组:催产素+盐酸罗哌卡因组(n=20)。肌注(im)苯甲酸雌二醇12 d,各组小白鼠每次每天2 mg·kg-1。Ⅰ组参照实验组注射时间等量腹腔注射(ip)生理盐水(0.9%氯化钠水溶液),Ⅱ组末次给致敏药物苯甲酸雌二醇后45 min先腹腔注射生理盐水(0.9%氯化钠水溶液)0.02 ml,30 min后缩宫素2 IU/只(应用0.9%氯化钠水溶液稀释至0.1 ml)腹腔注射(ip),Ⅲ组在末次给致敏药物苯甲酸雌二醇后45 min先腹腔注射0.25%盐酸罗哌卡因0.02 ml,30 min后腹腔注射(ip)缩宫素2IU/只(应用0.9%氯化钠水溶液稀释至0.1 ml)。观察并记录30 min内每只小白鼠的扭体反应次数及潜伏期。结果Ⅰ组未出现扭体反应,Ⅱ组扭体反应次数较多,经统计学处理两组间差异有统计学意义(P<0.01);Ⅲ组扭体反应次数明显少于Ⅱ组,扭体反应潜伏期明显长于Ⅱ组(P<0.01)。结论盐酸罗哌卡因腹腔注射能显著缓解宫缩痛模型小鼠的疼痛。 Objective To investigate the analgesic effect of ropivacaine intraperitoneal injection on the pains of uterus systole in mice, explore a new safe and effective analgesiaway for childbirth. Methods Sixty female mice were randomly divided into three groups, twenty in each group. Saline ( group I), oxytocin and saline (group II), oxytocin and ropivacaine (group III). All mice were intramuscular injected with estradiol benzoate at the dose of 2mg · kg-1 per day for 12 days. Mice in group I were intramuscular injected with saline at the dose of 0.12ml, mice in group II received saline (0.02ml) and Oxytocin (2IU) successively after last injection of estradiol benzoate, and mice in group III received ropivacaine (0.25%, 0.02ml) and Oxytocin (2IU) successively after last injection of estradiol benzoate. The number and latent t period of writhing in the 30min period after last administration were recorded. Results The number of writhing in groupIIwassignificantlymore than that in groupI ( P 〈 0. 01 ). The number of writhing in groupIII was less than groupII ( P 〈 0. 01 ), but the latent period was more than that in groupII ( P 〈 0.01 ). Conclusions Intraperitoneal injection of ropivacaine (0.25%) could effectively relieve the pain of uterus systole in miceinduced by oxytocin.
出处 《齐齐哈尔医学院学报》 2014年第4期473-474,共2页 Journal of Qiqihar Medical University
基金 南医大二附院青年启动基金课题"局麻药腹腔注射对小白鼠宫缩痛的影响"
关键词 盐酸罗哌卡因 腹腔注射 扭体反应 催产素 苯甲酸雌二醇 Ropivacaine Intraperitoneal injection Writhing Oxytocin Estradiol benzoate
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参考文献10

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