摘要
目的 观察紫杉醇联合奥沙利铂为主化疗方案治疗晚期胃癌的临床效果.方法 将2010年1月～2012年12月湖北省天门市第一人民医院肿瘤科72例胃癌晚期患者随机分为两组,每组36例.观察组采用紫杉醇、奥沙利铂和卡培他滨.对照组采用奥沙利铂、氟尿嘧啶和醛氢叶酸化疗.治疗后评价疗效、生活质量改变、不良反应以及治疗前后的血清癌胚抗原（CEA）、糖抗原（CA-199）和β2微球蛋白（β2-MG）比较.结果 观察组完全缓解（CR）3例,部分缓解（PR）18例,总有效率（RR）为58.3％.对照组CR 2例,PR 15例,RR为47.2％.观察组卡氏评分改善率（52.8％）高于对照组（41.6％）.观察组主要不良反应骨髓抑制、恶心、呕吐、脱发、肝功能损伤等方面均较对照组明显减轻,治疗后观察组的血清CEA[（15.68±2.72）ng/mL]、CA-199[（69.58±4.72） μg/mL]和β2-MG[（3.27±0.61）ng/mL]较对照组下降,两组比较差异均有统计学意义（P＜0.05）.结论 紫杉醇联合奥沙利铂治疗晚期胃癌具有提高化疗有效率、减轻化疗不良反应、提高患者生活质量的作用.
Objective To observe the efficacy of Paclitaxel combined with Oxaliplatin-based chemotherapy regimens in the treatment of patients with advanced gastric cancer.Methods 72 cases of advanced gastric cancer patients in Department of Oncology in the First People＇s Hospital of Tianmen City of Hubei Province from January 2010 to December 2012 were chosen and divided into two groups,with 36 cases in each group.Observation group were received Paclitaxel,Oxaliplatin and Capecitabine,while control group were treated with Oxaliplatin,Calcium Folinate combined with Fluorouracil.After therapy,the therapeutic effect,change of life quality and side effect were evaluated.Serum CEA,CA199 and β2-MG before and after treatment were compared.Results In observation group,3 patients had complete response,18 patients had partial response,the response rate was 58.3%.In control group,2 patients had complete response,15 patients had partial response,the response rate was 47.2%.The observation group KPS improvement rate （52.8%） was higher than that of control group （41.6%）.The untoward effect of observation group such as the arresting of bone marrow,nausea,vomit,alopecia and injury of liver function were all less than those of control group.Serum CEA [（15.68±2.72） ng/mL],CA199 [（69.58±4.72） μg/mL] and β2-MG [（3.27±0.61） ng/mL] of the observation group after treatment were lower than those of control group,there were significant differences （P 〈 0.05）.Conclusion The Paclitaxel combined with Oxaliplatin for patients with advanced gastric cancer can increase the response rate,lighten the untoward effect of chemotherapy,and enhance the quality of life.
出处
《中国医药导报》
CAS
2014年第6期56-58,61,共4页
China Medical Herald
基金
浙江省医药卫生平台骨干人才计划项目(A类)(编号2011RCA004)
关键词
紫杉醇
奥沙利铂
胃癌晚期
Paclitaxel
Oxaliplatin
Advanced gastric cancer
