摘要
目的探讨血清总前列腺特异性抗原(t-PSA)、游离前列腺抗原/总前列腺抗原(f-PSA/t-PSA)比值与超声联检对前列腺癌(PCa)的诊断价值。方法将38例经手术和病理证实的PCa患者与45例前列腺增生(BPH)患者和40名正常人的t-PSA、f-PSA/t-PSA比值检测结果进行对比,并和超声联检结果进行分析。结果 PCa患者血清t-PSA含量显著高于其它两组,差异有统计学意义(P<0.01)。t-PSA和f-PSA/t-PSA比值作为单一指标应用于诊断PCa时,灵敏度分别为47.37%、73.68%,准确性分别为51.81%、71.08%,与超声影像学三者联检,诊断PCa的灵敏度为94.73%,特异性为95.56%,准确性为95.18%。三者联检均高于其单检的敏感性,差异有统计学意义(P<0.01)。结论 t-PSA、t-PSA/f-PSA是诊断PCa的较好指标。血清t-PSA、t-PSA/f-PSA比值和影像学联检可大大提高对PCa的诊断率,对PCa患者早期诊断、早期治疗和监控有重要作用。
Objective To explore the clinical diagnostic value of ultrasonic combined with serum PSA,f-PSA/t-PSA ratio in carcinoma of prostate （PCa）. Methods There were 38 cases of PCa confirmed by surgery and patholog, 45 cases of benign prostatic hyperplasia （BPH） and 40 controls. Serum levels of t-PSA and f-PSA/t-PSA of 38 PCa patients, 45 BPH patients and 40 controls were determined and compared. The results of serum PSA, f-PSA/t-PSA, f-PSA/t-PSA ratio and the of ultrasonic results were statistical analyzed retrospectively. Results While the level of serum PSA in the PCa was evidently higher than the other two groups, the differences were statistically significant （P〈0.01）. The sensitivity of t-PSA and f-PSA/t-PSA ratio for diagnosing PCa were 47.37% and 73.68%, respectively; accuracy were 51.81% and 71.08%, respectively. The sensitivity and accuracy of serum t-PSA, f-PSA/t-PSA ratio combined with ultrasonic diagnosis were 94.73% and 95.18%, respectively. The sensitivity of serum t-PSA, f-PSA/t-PSA combined with ultrasonic was better than other methods（P〈0.01）. Conclusion T-PSA and t-PSA/f-PSA were useful indicators for diagnosing PCa. The combined detection of serum t-PSA, f-PSA/t-PSA and ultrasonic in PCa patients can improve the detective rate. Ultrasonic combined with serum t-PSA and f-PSA/t-PSA in detection of PCa play an important role in early diagnosis, treatment and monitoring of the disease.
出处
《热带医学杂志》
CAS
2014年第2期184-186,共3页
Journal of Tropical Medicine
