摘要
【摘要】目的探讨大容量肺灌洗术后肺表面活性物质（PS）恢复水平与肺顺应性的关系。方法选取观察对象、Ⅰ期、Ⅱ期尘肺患者各10例，测定肺灌洗后不同时间点的Ps恢复水平与肺顺应性值，并分析其关系。结果观察对象术前、术后0、10、30、60、90、120min的肺顺应性值分别为（39．5±6．7、28．3±5．6、31．5±5．2、37．6±4．4、38．0±5．3、38．7±5．5、39．2±5．3）ml／cmH：O，Ⅰ期尘肺为（38．8±5．1、25．1±6．1、28．4±6．8、30．5±5．9、36．3±5．5、37，3±5．4、38．2±4．5）ml／cmH20，II期尘肺为（32．9±6．1、20．3±6．0、24．3±5．4、25．1±5．4、26．8±5．8、27．8±4.8、32．8±4．5）ml／cmH2O；尘肺患者的肺顺应性随期别的增加，呈降低趋势，Ⅱ期患者的肺顺应性最低，组间比较，差异有统计学意义（P〈0．05）。观察对象术后30rain肺顺应性逐渐恢复到术前水平，I期尘肺术后60rain恢复到术前水平；Ⅱ期尘肺术后120min恢复到术前水平。与术后0min比较，观察对象、Ⅰ期、Ⅱ期尘肺患者术后10rain的Ps水平明显增高，差异有统计学意义（P〈0．05）。Ⅰ期、Ⅱ期尘肺患者术后30min的Ps水平明显高于术后10min，差异有统计学意义（F=4．27，F=20．40，P〈0．05）。观察对象、Ⅰ期、Ⅱ期尘肺患者术后60minPS水平明显高于术后10、30min，差异均有统计学意义（P〈0．05）。观察对象、I期、Ⅱ期尘肺患者肺灌洗后肺内Ps可在10～30min内提高，蒯顷应性恢复需要较长时间（30～90）min。PS恢复与肺顺应性有关。结论肺灌洗术后肺顺应性明显下降，随后逐渐恢复，期别越高，恢复时间越长。肺顺应性恢复较PS恢复延退。
Objective To investigate the relationship between the recovery levels of pulmonary surfactants （PS） and lung compliance after whole-lung lavage. Methods Patients with pneumoconiosis in different stages （healthy subjects, stage I, and stage II, n=10 for each group） were selected. The recovery levels of PS and lung compliance at different time points after whole-lung lavage were determined, and their relationship was analyzed. Results Before whole-lung lavage and at O, 10, 30, 60, 90, and 120 rain after the operation, the lung compliance levels were 39.5±6.7, 28.3±5.6, 31.5±_5.2, 37.6±_4.4, 38.0±5.3, 38.7±5.5, and 39.2±5.3 ml/cm H20 for healthy subjects, 38.8±5.1, 25.1±6.1, 28.4±6.8, 30.5±5.9, 36.3±5.5, 37.3±5.4, 38.2± 4.5, and 38.8±_5.1 ml/cm H20 for patients with stage I pneumoconiosis, and 32.9±_6.1, 20.3±_6.0, 24.3~5.4, 25.1±_ 5.4, 26.8 ±_5.8, 27.8 ±_4.8, and 32.8 ±_4.5 ml/cm H20 were for patients with stage II pneumoconiosis. It was observed that in patients with pneumoconiosis, the lung compliance levels showed a declining trend along with the increasing stage, reaching the lowest level in stage II patients; comparison between groups indicated a significant difference （P〈0.05）. For healthy subjects, 30 min was needed for restoring lung compliance to its preoperative level, while 60 and 120 rain were needed for stage I and stage II patients, respectively. Compared with that at 0 rain after operation, PS levels were elevated significantly at 10 min after operation in all patients （P〈O.05）, whereas for stage I and stage II patients, the PS levels at 30 rain after operation were significantly higher than that at 10 min （F=4.27, P〈0.05; F=20.40, P〈0.05）. For all patients, the PS levels at 60 min after operation were significantly higher than those at 10 and 30 min （P〈O.05）. After whole-lung lavage, the PS levels in all patients were restored to a large extent within 10-30 min, but the recovery of lung compliance needed 30-90 min. Conclusion After whole-lung la
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2014年第3期223-225,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
