摘要
门静脉系统是一个特殊的循环系统。该系统具有两大血管床：一个是以肝窦区域为主的肝内血管系统，另一个是以脾脏、肠系膜血管为主的肝外血管系统。肝内、外血管床的收缩和舒张在肝硬化门静脉高压的病理机制中起到至关重要的作用。RhoA／ROCK通路在介导血管平滑肌收缩的非钙依赖途径中发挥着重要作用。该通路可以在肝内循环系统调节肝内小血管及肝星形细胞的收缩，在肝外系统影响以血管低反应性为特点的高动力循环。因此，深入探讨RhoA／ROCK通路参与门静脉高压的机制，有利于为防治门静脉高压提供新的治疗靶点。
The hepatic portal system is a unique circulatory system that connects two systems of capillary beds ; one in the wall of the small intestine and spleen and the second in the sinusoidal area of the liver. Therefore, alterations in vasoreactivity （vasodilation and vasoconstriction） play a critical role in the pathophysiology of portal hypertension （PHT）. The RhoA/ ROCK pathway exerts an important role in the Ca2＋ -independent mechanism in vascular smooth muscle （VSM）. This mechanism not only modulates the constriction of intrahepatic small vessels and hepatic stellate cells （HSCs） but also effects the hyperdynamic circulation due to vascular hyporesponsiveness. Understanding the detailed mechanism and role of the RhoA/ROCK signal pathway in portal hypertension could be of great utility in providing a new target for portal hypertension therapy.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2014年第3期235-240,共6页
Chinese Journal of Hepatobiliary Surgery
