摘要
目的观察含不同浓度锶矿泉水对正常大鼠的血清ALT、AST、LDH、BUN、Cr、甘油三酯、HDL和胆固醇含量的影响。方法健康Wistar大鼠，体重150～170g，雄雌各半，随机分为试验组A、B、C、D（矿泉水锶含量分别为2、4、6、8mg／L）和对照组E（自来水），每组42只（n=42）。除对照组饮用自来水外，其他各试验组分别饮用对应舍锶量的长江雪岭天然矿泉水。各组分别于第0、1、2、3、4、5、6个月随机处死6只大鼠，采血检测ALT、AST、LDH、BUN、Cr、甘油三酯、HDL和胆固醇含量，并取各组大鼠的心、肝、肾脏组织，做HE染色，观察形态变化。结果各试验组血清ALT、AST、LDH、Cr、甘油三酯、HDL和胆固醇含量与对照组比较差异均无统计学意义（P〉0．05），仅A组血清BUN含量较对照组下降，差异有统计学意义（P〈0．05）。各时间点试验组心、肝、肾脏形态与对照组比较差异无统计学意义（P〉0．05）。结论含锶矿泉水对大鼠血清生化指标无不良影响。
Objective To investigate the influence of trace element strontium on the content of rats＇ serum ALT, AST, BUN, Cr, LDH, HDL, triglyeerides and total cholesterol. Methods Wistar rats weighing 150-170 g, half male and half female, were randomly divided into group A, B, C, D （mineral water with Sr 2, 4, 6, 8 mg/L） and group E （tap water）. Each group had 42 rats （n=42）. 6 rats in each group were randomly sacrificed at 0, 1, 2, 3, 4, 5 and 6th month, and blood samples were collected. Serum ALT, AST, BUN, Cr, LDH, HDL, triglycerides and total cholesterol were tested. Hearts, livers and kidneys were stained by HE for morphology analysis. Results There was no significant difference in the content of serum ALT, AST, Cr, LDH, HDL, triglycerides and total cholesterol between group A, B, C, D and E at each time point. （P 〉 0. 05）. The contents of BUN in group A was significantly lower than that in group E （P 〈 0. 05）. There was no significant difference in the morphology of kidney, heart and liver between group A, B, C, D and E. Conclusion Trace element strontium had no significant effect on the content of serum ALT, AST, LDH, BUN, Cr, HDL, triglycerides, total cholesterol, and the morphology of kidney, heart and liver in rats.
出处
《中国食品卫生杂志》
北大核心
2014年第2期133-136,共4页
Chinese Journal of Food Hygiene
关键词
微量元素
锶
大鼠
血清
矿泉水
甘油三酯
胆固醇
毒理学实验
Trace element
strontium
rat
serum
mineral water
triglycerides
cholesterol
toxicological experiment
