摘要
目的通过Meta分析方法分析丹参酮ⅡA磺酸钠注射液治疗冠心病心绞痛的有效性及安全性。方法计算机检索Cochrane图书馆临床对照试验资料库、Embase、Pubmed、中文科技期刊数据库、万方数字化期刊库、中国(CNKI)学术文献总库,按纳入与排除标准选择随机对照试验、评价质量,提取资料,并用RevMan5.2软件对数据进行Meta分析。结果共初检出182篇文献,经筛选最终纳入7篇关于丹参酮ⅡA磺酸钠注射液治疗冠心病心绞痛的随机对照研究。以心绞痛缓解为疗效尺度:χ2=2.24,df=6,P=0.90,合并OR=3.08,95%CI[1.95,4.87],Z=4.83(P<0.00001);以心电图为疗效尺度:χ2=2.74,df=6,P=0.84,合并OR=3.20,95%CI[2.10,4.88],Z=5.39(P=0.00001)。结论丹参酮ⅡA磺酸钠注射液治疗冠心病心绞痛安全有效。
Objective：To detect the effectiveness and safety of Tanshinone Ⅱ A Silas injection on angina pectoris.Methods：Trails on angina pectoris treated by Tanshinone Ⅱ A Silas injection were retrieved in Cochrane Library,Ovid-medline,Pubmed Embase,CNKI,Wanfang,VIP and CBM.These articles accordance with inclusion criteria were analyzed statistically by RevMan 5.2 soft.Results：A total of 7 random control trails in 182 subjects were included in this study.With the angina remission as the effect scales,x^2=2.24,df=6,P=0.90 and the pooled OR and 95%CI were 3.08 [1.95,4.87].The Z values were 4.83 （P〈 0.00001）.With the ECG improvement as the effect scales,x^2=2.74,df=6,P=0.84 and the pooled OR and 95%CI were 3.08 [2.10,4.88].The Z values were 5.39 （P=0.00001）.Conclusion：Tanshinone Ⅱ A sodium sulfonate injection is effective and safe for angina pectoris.
出处
《中国中医急症》
2014年第3期413-415,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
吉林省科技厅科研项目(No.200905138)
关键词
丹参酮ⅡA磺酸钠注射液
冠心病
心绞痛
META分析
Tanshinone Ⅱ A Sodium sulfonate injection
Coronary heart disease
Angina pectoris
Meta analysis
