摘要
目的探讨经外周静脉输注脐带血间充质干细胞移植联合口服中药治疗失代偿期肝硬化的临床效果及不良反应。方法 22例肝硬化失代偿期患者采取外周静脉输注途径移植脐带血间充质干细胞,移植后当天起连续给予口服中药汤剂10 d,分别于移植术后观察患者临床症状、肝功能及不良反应。结果术后4周、8周肝功能明显改善(P<0.05),患者临床症状也有不同程度改善,未见明显不良反应和并发症发生。结论经外周静脉输注脐带血间充质干细胞移植联合口服中药治疗失代偿期肝硬化短期内有效、安全。
Objective To investigate the clinical therapeutic and adverse effect of human umbilical cord mesenchymal stem cells （UC-MSC） transplantation combined oral administration of traditional Chinese medicine treatment in patients with decompensated liver cirrhosis. Methods Total of 22 patients with decompensated liver cirrhosis treated with human UC-MSC transplantation via peripheral vein, combined oral administration of traditional Chinese medicine 10 days. The clinical symptoms, ascites, biochemical test（ALT, ALB and PT）were observed. Results Significant improvement in chnical symptom, biochemical testwas found after 4,8 weeks （P〈O.05）. There was no patient suffered severe complications and adverse reactions associated with transplantation. Conclusions UC-MSC transplantation via peripheral vein combined oral administration of traditional Chinese medicine treatment in patients with decompensated liver cirrhosis was effective and safety in short term.
出处
《基层医学论坛》
2014年第1期16-18,共3页
The Medical Forum
关键词
肝硬化
脐带血间充质干细胞
干细胞移植
中药
Umbilical cord mesenchymal stem cell Stem cells transplantation liver cirrhosis TraditionalChinese medicine
