摘要
目的探讨并比较自体血清滴眼液和小牛血去蛋白提取物眼用凝胶在翼状胬肉切除术后角膜修复中的治疗效果。方法对2012年2月至2013年2月在武汉市中心医院眼科就诊的60例翼状胬肉患者行翼状胬肉切除联合角膜缘干细胞移植术，术后分别应用自体血清滴眼液或小牛血去蛋白提取物眼用凝胶点眼。术后随访3个月，观察两种滴眼液在翼状胬肉术后角膜修复中的治疗效果。结果自体血清滴眼液组术后3d时自觉异物感、卡痛等症状明显减轻，4d时仅有轻度异物感；小牛血去蛋白提取物眼用凝胶组术后4d时畏光、流泪开始减轻，6d时异物感明显消失。角膜上皮平均修复时间自体血清组（2．55±1．31）d，与小牛血去蛋白提取物眼用凝胶组（3．55±1．23）d相比，差异有统计学意义（P〈0．05）。术后视力恢复两组对比差异无统计学意义（P〉0．05）。手术治疗后3个月，所有患者无感染、排斥及其他并发症。结论自体血清滴眼液和小牛血去蛋白提取物眼用凝胶均能有效地治疗翼状胬肉切除术后的角膜上皮缺损，两者疗效无明显差异。自体血清滴眼液组患者术后相对恢复较快，自觉异物感、不适感较轻微。
Objective To compare the efficacy of autologous serum eye drops and deproteinized calf blood extract eye gel for corneal repair in the treatment of pterygium surgery. Methods A total of 60 cases （60 eyes） were received pterygium resection combined with limbal-conjunctival autogratting. After sur- gery, they were randomly assigned to autologous sertun eye drops （n =30） or deproteinized calf blood ex- tract eye gel （n =30）. Corneal wound healing, the presence or absence of conjunctival proliferation and hy- peremia was analyzed at 3 months postoperatively. Results Patients received autologous serum eye drops felt less foreign body sensation, pain and other symptoms on the 3rd day and only mild foreign body sen- sation on the 4th day. In the extract eye gel group, photophobia and lacrimation began to ease after the 4th day; the foreign body sensation apparently disappeared on the 6th day. The Mean time of corneal epi- thelium repair were （2.55±1.31） days in the autologons serum group and （3.55±1.23） days in the deprotein- ized calf blood extract eye gel group, which showed significant difference （P 〈0.05）. Visual acuity be- tween the two groups showed no significant difference （P 〉0.05）. Three months after surgery, there were no significant complications associated with the use of autologous serum eye drops or deproteinized calf blood extract eye gel including infection and rejection. Condusions Both of the autologous serum eye drops and deproteinized calf blood extract eye gel are effective for corneal repair in the treatment of pte- rygium. Patients undergoing autologous serum eye drops experience faster recovery, less foreign body sensa- tion and mild discomfort compared with those undergoing deproteinized calf blood extract eye gel.
出处
《中国实用眼科杂志》
CSCD
北大核心
2014年第3期368-370,共3页
Chinese Journal of Practical Ophthalmology
