摘要
目的通过观察丹参川芎嗪注射液对老年不稳定型心绞痛(UAP)患者血流变学、超敏C反应蛋白(hs-CRP)和血脂代谢的影响,探讨其对老年UAP患者的治疗作用。方法将106例老年UAP患者随机分为治疗组54例和对照组52例,对照组根据指南给予治疗,治疗组在对照组基础上加用丹参川芎嗪注射液10 mL加入0.9%生理盐水250 mL中静脉滴注,1次/d,连续15 d,比较两组治疗前后hs-CRP、血流变学及血脂各项指标的变化情况,同时分析两组治疗效果。结果治疗后两组患者临床疗效总有效率分别为96.30%、82.63%,两组比较差异有统计学意义(P<0.05)。治疗后两组患者hs-CRP均较治疗前下降,血流变学及血脂代谢各项指标较治疗前改善,但治疗组改善更明显,两组比较差异有统计学意义(P<0.05),两组患者均未出现严重不良反应。结论在常规治疗基础上加用丹参川芎嗪注射液治疗老年冠心病UAP患者临床疗效显著,与其可显著降低患者血清hs-CRP水平,并有效改善血流动力学及血脂代谢状况等有关。
Objective To observe the effect of Danshen ligustrazine for injection on blood theology, high-sen- sitivity C-reactive protein （hs-CRP） and fat metabolism on elderly patients with unstable angina pectoris （UAP）. Methods 106 elderly patients with UAP were randomly divided into treatment group （ n = 54 ） and control group （ n = 52 ）. Control group was treated according to the UAP treatment guidelines, treatment group was added with Danshen li- gustrazine for injection 10 mL in 0. 9% sodium chloride 250 mL iv drip once a day,for 15 consecutive days on the ba- sis of control group. The changes of hs-CRP,indexes of blood rheology and fat metabolism were measured before and after treatment. Results The improvements of angina and ECG in the treatment group were better than those in the control group （ P 〈 0. 05 ）. After treatment, the hs-CRP in the two groups decreased than before treatment, and the treat- ment group decreased significantly than that of control group （ P 〈 0. 05 ）. After treatment, the indexes of blood theolo- gy and fat metabolism were significantly improved than before treatment （ P 〈 0. 05 ）. There was no obvious adverse re- actions in the two groups after treatment. Conclusion Danshen ligustrazine for injection has a good curative effect on elderly patients with UAP, which might be related to reducing hs-CRP,improving blood rheology and fat metabolism.
出处
《实用药物与临床》
CAS
2014年第3期267-270,共4页
Practical Pharmacy and Clinical Remedies
关键词
丹参川芎嗪
血流变学
超敏C反应蛋白
血脂
不稳定型心绞痛
老年患者
Danshen ligustrazine for injection
Blood rheology
High-sensitivity C-reactive protein
Fat metabo-lism
Unstable angina pectoris
Elderly patients
