摘要
目的探讨IGFBP-3、P53在结肠癌发病机制中的作用和临床意义。方法应用免疫组化SP法检测67例结肠癌组织和34例正常结肠黏膜中IGFBP-3、P53的表达情况。结果①IGFBP-3在结肠癌中的阳性率为74.6%,显著低于对照组的94.1%(P=0.018),P53在结肠癌中的阳性率为52.2%,显著高于对照组的2.9%(P<0.001);②IGFBP-3在结肠癌中的表达与TNM分期、淋巴结转移、远处转移有关(P<0.05);P53在结肠癌中的表达与TNM分期、淋巴结转移有关(P<0.05),二者与其他因素均无关(P>0.05)。③IGFBP-3与P53的表达呈负相关性(P=0.004)。结论 IGFBP-3与P53在结肠癌中的表达与多项临床病理指标具有相关性,联合检测IGFBP-3、P53可能成为结肠癌评估预后新的生物学指标。
[ Objective ] To investigate the roles and the clinical significance of IGFBP-3 and P53 in the pathogenesis of colon cancer. [ Methods ] The expressions of IGFBP-3 and Ps3 were detected in 67 cases of colon cancer tissues and 34 cases of normal colon mucosa tissues by SP immunohistoehemical technology. [ Resluts ] （1） The IGFBP-3 positive expression rate of 74.6% in colon cancer was significantly lower than this of 94.1% in control group （P=0.018）. The P53 positive expression rate of 52.2% in colon cancer was significantly higher than this of 2.9% in control group （P 〈0.001）; （2） There were correlations between the IGFBP-3 expression and these clinic pathological parameters in colon cancer, including the TNM stage, lymph node metastasis and distant metastasis （P〈0.05）; The P53 expression in colon cancer also showed correlations to the TNM stage, lymph node metastasis （P〈0.05）, both of the two are independent of other factors （P〉0.05）. （3） The expressions of IGFBP-3 and P53 were negatively correlated （P=0.004）. [ Conclusion ] There were correlations between the expressions of IGFBP-3and P53 in colon cancer and various clinic pathological parameters in colon cancer. Combined detections of IGFBP-3 and P53 could become new biomarkers in assessment of colon cancer prognosis.
出处
《中国医学工程》
2014年第1期5-6,8,共3页
China Medical Engineering
