摘要
目的:探讨卡维地洛联合螺内酯治疗高血压的治疗效果。方法:选取218例高血压患者,随机分为观察组(118例)与对照组(90例),观察组停用原治疗药物1w以上后用卡维地洛联合螺内酯治疗,对照组在原有治疗基础上加用螺内酯治疗,比较两组患者的副作用发生率、治疗总有效率、左室舒张末期内径变化和左室收缩末期内径变化。结果:观察组治疗总有效率明显高于对照组(97.46%v.s 86.67%,P<0.01),副作用发生率明显低于对照组(3.39%v.s 12.22%,P<0.05),左室舒张末期内径变化明显大于对照组(7.81±1.97 v.s 4.85±1.62,P<0.01),左室收缩末期内径的变化均明显大于对照组(9.45±2.32 v.s6.92±1.79,P<0.01)。结论:卡维地洛联合螺内酯治疗高血压效果比普通治疗效果较好。
Objective.. To study the clinical effects of carvedilol combined with spironolactone on hypertension. Method： Two hun- dred and eighteen cases of hypertension patients were randomly divided into observation group （118 cases） and control group （118 cases）. The patients in observation group were treated with carvedilol and spironolactone when stopped using the original drugs more than 1 week. The control group added using spironolactone on the basis of the original treatment. The side effects, the total effective rate, the decreased value of LVEDD and LVESD were compared. Results： The effective rates were obviously higher in the observation group than in the control group （97. 46% v. s 86. 67%, P〈0. 01）. The side effects were obviously lower in the observation group than in the control group （3.39% v. s 12. 22N, P〈0. 05）. The decreased value of LVEDD and LVESD were obviously higher in the observation group than in the control group （7. 81 1.97; 9.45 2. 32 v. s 4. 85 1.62; 6.92 1.79, P〈0.01）. Conclusion. The combination drug treatment of carvedilol and spironlactone is more effective to treat hypertension than average treatment.
出处
《四川生理科学杂志》
2014年第1期19-21,共3页
Sichuan Journal of Physiological Sciences
关键词
高血压
卡维地洛
螺内酯
治疗
Hypertension
Carvedilol
Spironolactone
Treatment
