摘要
目的探讨支气管肺泡灌洗液与血清中肿瘤标志物检测在肺癌的临床诊断价值。方法测定患者支气管肺泡灌洗液与血清中的癌胚抗原(CEA)、鳞状细胞癌相关抗原(SCC)和神经元特异性烯醇化酶(NSE)以及可溶性细胞角蛋白19片段(CYFRA21-1)的含量。结果研究组血清和支气管肺泡灌洗液中CEA、SCC和NSE以及CYFRA21-1含量均明显高于对照组(P<0.05)。支气管肺泡灌洗液与血清中不同病理类型和不同临床分期患者的CEA、SCC和NSE以及CYFRA21-1比较有统计学意义(P<0.05)。结论检测支气管肺泡灌洗液中的肿瘤标志物对肺癌的诊断效果明显的由于检测血清中的肿瘤标志物诊断效果,对患者的病情程度和预后均具有一定的临床应用价值。
Objective To investigate the value of bronchoalveolar lavage fluid and serum tumor markers in lung cancer diagnosis. Methods The content of carcinoembryonic antigen （CEA）, squamous cell carcinoma antigen （SCC） and neuron-specific enolase （NSE） and soluble cytokeratin 19 fragment （CYFRA21-1） in serum and lavage fluid were measured. Results The serum and bronchoalveolar lavage fluid CEA, SCC and NSE and CYFRA21-1 levels were significantly higher in the observation group than in the control group （P〈0.05）. There were significant difference in CEA, SCC and NSE and CYFRA21-1 between bronchoalveolar lavage fluid and serum of different pathological types and different clinical stages （P〈0.05）. Conclusion Detection of bronchoalveolar lavage fluid tumor markers has certain clinical significance in the diagnosis of lung cancer
出处
《临床肺科杂志》
2014年第4期712-714,共3页
Journal of Clinical Pulmonary Medicine
