摘要
为评价莪术油/(麦芽糊精-Povacoat)微囊的质量,建立了硫酸香茅醛显色测定其载药量和包封率的方法。对莪术油乙醇溶液进行波长扫描,确定508nm为最大吸收波长,显色稳定性试验表明,反应液在150min内吸光度较稳定。莪术油检测浓度在0.199 2μg/mL^9.960μg/mL范围内线性关系良好(A=0.094 7C-0.001 2,r=0.999 3),微囊的载药量测定和包封率测定的方法回收率分别为99.6%和99.1%。经测定,3批微囊的载药量为51.5mg/g^53.2mg/g,包封率为88.2%~90.7%。
In order to evaluate the quality of Zedimry turmeric oil/（maltodextrin - Povacoat） microcapsules（ZTO/M- P Mcs）, a sulfuric acid- vanillin coloration method for determination of drug loading capacity and encapsulation efficiency was developed. Wavdength seanned on the ZTO ethanol solution was determined at 508nm as the maximum absorption wavelength. Color stability tests showed that the absorbance of reac- tion solutions was stabled at 150 minutes. Absorbance and concentration of ZTO had a good linear relationship in the range of 0.199 2μg/mL - 9.96μg/mL（ A = 0.094 7C - 0. 001 2, r = 0.999 3）, the average recovery of determination of drug loading capacity and encapsulation efficien- cy were 99.6% and 99.1% respectively. According to assay results of 3 batches, drug loading was 51.5mg/g - 53.2mg/g; Encapsulation effi- ciency was 88.2% - 90.7%.
出处
《特产研究》
2014年第1期44-48,共5页
Special Wild Economic Animal and Plant Research
