摘要
目的:观察局部晚期食管癌同步放化疗后血清C-反应蛋白(CRP)水平的变化,分析CRP水平与急性放射性食管炎的相关性。方法:对35例局部晚期食管癌患者给予调强放疗同步顺铂+氟尿嘧啶方案化疗。在患者治疗前及治疗后1周抽血测血清CRP水平。急性放射性食管炎按RTOG急性放射性损伤标准评价。对血清CRP水平与放射性食管炎的关系进行统计学分析。结果:患者治疗前、后CRP分别为(16.9±11.2)mg·L-1和(25.34±11.65)mg·L-1,治疗后CRP明显升高(P<0.05);患者治疗后CRP及CRP升高水平与放射性食管炎的严重程度相关(P<0.05)。结论:局部晚期食管癌患者行同步放化疗后血清CRP升高,且CRP升高在一定程度上可预测放射性食管炎的严重程度。
Objective： To explore the variance of serum C-reactive protein （CRP） level in patients with local advanced esophagus cancer treated by concurrent chemo-radiotherapy and to analize the relationship of serum CRP and the severity of radiation esophagitis. Methods： A total of 35 patients with local advanced esophagus cancer were treated by intensity modulated radiation therapy （IMRT）, and intravenous infusion of cisplatin plus fluorouracil was taken concurrently. Serum CRP level was measured before and one week after therapy. Radiation esophagitis was evaluated according to the toxicity criteria of RTOG. The relationship of serum CRP and radiation esophagitis was determined by statistic analyze. Results： Serum CRP level significantly elevated from （16.9 ± 11.2） mg · L ^- 1 before treatment to （25.34 ± 11.65 ） mg · L ^- 1 one week after treatment （ P 〈 0.05 ）. Both serum CRP level and serum CRP level variance after treatment were correlated to the severity of radiation esophagitis（P 〈 0.05 ）. Conclusion： Serum CRP level elevate in patients with developed esophagus cancer who have been treated by concurrent chemo-radiotherapy. The serum CRP level variance may predict the severity of radiation esophagitis to some extent.
出处
《现代医学》
2014年第2期158-160,共3页
Modern Medical Journal
关键词
食管癌
同步放化疗
放射性食管炎
C-反应蛋白
esophagus cancer
concurrent chemo- radiotherapy
radiation esophagitis
C- reactive protein
