摘要
目的:探讨非高密度脂蛋白胆固醇(non-HDL-C)水平与2型糖尿病(T2DM)微血管病变的相关性。方法:测定134例T2DM患者总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,根据公式non-HDL-C=TC-HDL-C计算出non-HDL-C含量,并与60例体检健康者(正常对照组)进行比较。结果:T2DM组TC、TG、LDL-C及non-HDL-C均高于正常对照组,T2DM合并微血管病变患者上述指标均高于T2DM无微血管病变患者(P<0.05);HDL-C明显低于T2DM无微血管病变患者(P<0.05)。T2DM无微血管病变患者HDL-C略低于正常对照组(P>0.05)。T2DM微血管病变与TC、TG、LDL-C、non-HDL-C等指标呈正相关,与HDL-C呈负相关,且non-HDL-C与T2DM微血管病变之间相关性优于TG、TC和LDL-C。结论:脂质代谢紊乱的敏感指标non-HDL-C与T2DM微血管病变之间具有较好的相关性。
Objective： To investigate the correlation between the levels of non-high density lipoprotein cholesterol （ non- HDL- C ） and microangiopathy in type 2 diabetes （ T2DM ）. Methods： The levels of total cholesterol （ TC ）, triglyceride（TG）, high-density lipoprotein cholesterol （HDL-C ） and low-density lipoprotein cholesterol （LDL-C ） were detected in 134 patients with T2DM. The formula（ non-HDL-C = TC -HDL-C） was used to calculate the level of non- HDL- C, and then compared with 60 normal controls. Results： The level of TC, TG, LDL- C, and non-HDL-C in patients with T2DM were higher than those in control group, and the cases of T2DM with microangiopathy group were higher than those without microangiopathy group （P 〈 0.05 ） ; the level of HDL- C was significantly lower compared with without microangiopathy group （ P 〈 0.05 ）. There was no significant difference in the level of HDL-C between T2DM without microangiopathy group and control group. Furthermore, there was a positive correlation between T2DM with microangiopathy and TC, TG, LDL-C, non-HDL-C, and while there was a negative correlation between T2DM with microangiopathy and HDL-C, moreover, correlation of non-HDL-C was obviously stronger than that of TC, TG, and LDL-C. Conclusion： As a sensitive indicator of lipid metabolism disorders, it has much better correlation between non-HDL-C and type 2 diabetics with microangiopathy.
出处
《现代医学》
2014年第2期121-124,共4页
Modern Medical Journal
关键词
非高密度脂蛋白胆固醇
2型糖尿病
微血管病变
non-high density lipoprotein cholesterol-C
type 2 diabetes mellitus
microangiopathy
