摘要
目的 探讨右美托咪啶对腹腔镜胆囊切除患者红细胞变形性的影响.方法 选取我院择期行腹腔镜胆囊切除术患者40例,按随机数字表法分为2组：右美托咪啶组（D组）和对照组（C组）,每组20例.2组患者采用相同的麻醉方式,D组在诱导前给予右美托咪啶0.5 μg/kg的负荷量泵注10 min,随后改为0.5 μg·kg-1·h-1持续至气腹结束;C组在相同时间给予等量的生理盐水,静脉泵入至气腹结束.记录麻醉前（T0）以及手术结束时（T1）红细胞变形指数（EI）和血细胞比容（Hct）,手术时间、术中失血量以及麻醉药用量.结果 C组T1时EI（0.90±0.04）较T0时EI（0.81±0.06）显著增高,差异有统计学意义（P〈0.05）;D组T1时EI（0.85±0.06）较T0时EI（0.82±0.07）有所升高,但差异无统计学意义（P〉0.05）.D组瑞芬太尼和丙泊酚用量与C组相比显著减少（P〈0.05）.结论 腹腔镜胆囊切除术中使用右美托咪啶可以改善患者红细胞变形能力,减少患者术中以及术后并发症,改善患者远期预后.
Objective To study the impact of dexmedetomidine on the deformability of erythrocyte in patients with laparoscopic cholecystectomy. Methods 40 patients scheduled for laparoscopic choleeysteetomy were randomly divided into 2 groups （ n = 20 each） ： dexmedetomidine group （ group D, 0.5 txg/kg loading within 10 min and 0.5 μg·kg-1·h-1 maintenance to the end of pneumoperitoneum） and control group （group C, normal saline administered in the same way）. The induction and maintenance of anesthesia of 2 groups were identical. Erythrocyte deformability index （EI） and hematocrit （Hct） were assayed before anesthesia （T0 ） and after the operation （T1 ）. Operation time, intraoperation blood loss and the amount of anesthetics were recorded. Results Compared with TO （ 0.81 ±0.06） , EI was significantly increased at T1 in group C （P 〈 0.05）. Compared with TO （0.82 ±0.07）, EI was increased at T1 in group D, but it showed no statistically significant difference （ P 〉 0.05 ）. Compared with group C, the consumption of remifentanil and propofol were significantly reduced in group D （ P 〈 0.05 ）. Conclusions Densmedetomidine can improve the deform- ability of erythrocyte, reduce intraoperative and postoperative complications and improve the long - term prognosis of pa- tients.
出处
《徐州医学院学报》
CAS
2014年第1期34-36,共3页
Acta Academiae Medicinae Xuzhou
关键词
右美托咪啶
胆囊切除术
腹腔镜
红细胞变形性
dexmedetomidine
cholecystectomy
laparoscopy
erythrocyte deformability
