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肿瘤坏死因子α诱导蛋白家族与疾病的关系 被引量:14

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摘要 肿瘤坏死因子(TNF)-α主要由活化的单核/巨噬细胞产生,能杀伤和抑制肿瘤细胞、促进中性粒细胞吞噬、抗感染、引起发热,诱导肝细胞急性期蛋白合成、促进髓样白血病细胞向巨噬细胞分化、促进细胞增殖和分化,是一种重要的炎症因子,而且参与某些自身免疫性疾病的病理损伤。肿瘤坏死因子α诱导蛋白(TNFAIP)是一个包含有多种蛋白的蛋白质家族,与多种自身免疫性疾病、肿瘤等有关,对TNFAIP家族的研究可以为临床多种疾病的诊断和治疗提供重要的帮助。
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2014年第4期433-436,共4页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金(81071327 81270142) 河南省科技厅国际合作项目(114300510026)
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