摘要
目的:评定高效液相色谱(HPLC)法测定卡托普利片含量的测量不确定度。方法:建立HPLC法测定卡托普利片的含量的数学模型,分析测量不确定度的影响因素并对各因素进行评估,给出扩展测量不确定度报告。结果:HPLC法测定卡托普利片含量的扩展测量不确定度为1.2%,测量结果表示为(100.3±1.2)%,k=2。结论:明确产生不确定度的主要来源,可为有效地控制该含量测定方法的准确性提供可靠的理论依据。
OBJECTIVE： To establish a method for the uncertainty evaluation for the determination of Captopril tablets by HPLC. METHODS： Mathematical model was established for HPLC for the content determination of Captopril tablets to identify influential factors of uncertainty, evaluate the uncertainty factors and report expanded measurement uncertainty. RESULTS： The expanded uncertainty for the content determination of Captopril tablets as 1.2%, and the result of content determination was （ 100.3 ± 1.2）% （k=2）. CONCLUSIONS： Main source of uncertainty should be clear and definite, which can provide theory evidence for accuracy control of the measurement method.
出处
《中国药房》
CAS
CSCD
2014年第12期1140-1143,共4页
China Pharmacy
