摘要
次黄嘌呤脱氢酶(inosine 5'-monophosphate dehydrogenase,IMPDH)是GMP从头合成途径的限速酶,多种疾病会影响其活性与表达。以它为靶点的药物已广泛应用到抗病毒、免疫抑制、抗肿瘤等领域。IMPDH不仅充当核苷酸代谢酶的角色,它还具有多种其他生物学功能,在疾病及生理过程中发挥着重要作用。本文就IMPDH的基本功能、催化机制、生物学功能、抑制剂分类及其作为药物靶点的意义和研究进展作一综述,希望为进一步发现IMPDH的生物学功能与新型抑制剂提供参考。
Inosine 5＇-monophosphate dehydrogenase （IMPDH） is a key enzyme of de novo GMP biosynthesis. The expression and activity of IMPDH can be affected by diseases and physiological process. It is the drug target for anticancer, antiviral, antimicrobial and immunosuppressive therapeutics. Not only catalytic action but the other biological functions of IMPDH also play an important role in diseases. The basic functions, mechanism of catalysis, classification will be illustrated in this review. It is functions of IMPDH. of inhibitors, biological functions and expected to be helpful to the discovery the latest advances to IMPDH of new inhibitors and biological
出处
《药学学报》
CAS
CSCD
北大核心
2014年第3期285-292,共8页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81173073)
关键词
次黄嘌呤脱氢酶
催化机制
药物靶点
生物学功能
抑制剂
inosine 5＇-monophosphate dehydrogenase
mechanism of catalysis
drug target
biologicalfunction
inhibitor
