摘要
目的通过动物实验探讨 ＭＡＦ对急性硫化氢中毒的治疗作用。方法将４０ 只大鼠分为正常对照组、染毒对照组、美蓝求治组、４－ＤＭＡＰ救治组。以致死浓度的硫化氢染毒２ ｍｉｎ，对两组救治组动物分别给以美蓝和４－ＤＭＡＰ进行急救，２ ｈ后做相应生化及病理检查。结果两救治组 ＭＨｂ、 ＳＭＨｂ显著高于两对照组，４－ＤＭＡＰ组 ＭＨｂ、ＳＭＨｂ明显高于美蓝组；染毒对照组片组织明显充血、水肿，两救治组主要表现为充血。结论ＭＦＡ对急性硫化氢中毒动物起到解毒作用，而４－ＤＭＡＰ效果优于美蓝。
Objective To study the therapeutic effect of MFA against acute H2S intoxication. Methods Forty rats were divided into four groups: normal control group, poisoned control group, methylene blue group and 4-DMAP group. The later three groups were exposed to lethal concentration of H2S for 2 minutes, and then the later two rat groups were given methylene blue and 4-DMAP respectively. After 2 hours observation all the animals were killed, and the levels of CK, LDH, AST, ALT, Tb, MHb and SMHb in blood and pathological changes of lung were examined. Results The levels of MHb and SMHb in the two MFA treated groups increased significantly, and those in 4-DMAP group were even higher than those in methylene blue group. The lung tissues in poisoned control group were mainly hyperemia and partly edema, whereas the lungs of the two treated groups mainly appeared hyperemia. Conclusion MFA was proved to be antidotal to H2S poisoning, however, the efficacy of 4-DMAP seemed to be better than that of methylene blue.
出处
《中国职业医学》
CAS
北大核心
2001年第1期15-18,共4页
China Occupational Medicine
关键词
硫化氢中毒
高铁血红蛋白生成剂
治疗
实验研究
Hydrogen sulfide poisoning, methemoglobin forming agent(MFA), 4-DMAP, methylene blue
