摘要
目的 观察以树突细胞疫苗为主的主动免疫治疗 ,对人乳头瘤病毒感染致反复复发生殖器尖锐湿疣的临床疗效 .方法 将 39例反复复发 3次以上 ,顽固型尖锐湿疣患者 ,按知情同意原则 ,随机分为治疗组和对照组 ,两组均首先行冷冻或高频电刀治疗 ,以去除大部分疣体组织 ,随后对照组用干扰素、抗病毒药物治疗 ,治疗组则采用主动免疫治疗 .结果 治疗组复发率为 2 0 % ,复发间期平均 4wk,细胞免疫功能有显著改善 ;对照组复发率 80 % ,复发间期 7d.结论 主动免疫治疗方法对于反复复发、顽固型人乳头瘤病毒感染的生殖器尖锐湿疣有显著疗效 。
AIM To investigate whether immunotherapy have the capacity to stimulate immunoresponse against condyloma acuminatum (CA) caused by human papillomavirus (HPV), and whether the immunotherapy is effective to recurrent CA. METHODS Thirty-nine cases of recurrent CA were randomly divided into two groups: the treatment group and the control group. The former contained 19 cases and the later 20 cases. All cases in both groups were given laser or freezing therapy at first, then cases in control group additionally accepted INF-αand anti-virus drug, cases in treatment group additionally accepted immunotherapy only. RESULTS Recurrent rate in the control group was 80%, but in the treatment group, the recurrent rate was only 20%, the time between treatment and recurrent being 7 days in the control group but 4 weeks in the treatment group (P<0.05), and the immune functions CD3, CD4, CD8 were improved in the treatment group (P<0.05). CONCLUSION Immunotherapy including dendritic cells can reduce recurrent rate, extend recurrent time of CA caused by HPV and improve patients' immune function.
出处
《第四军医大学学报》
北大核心
2001年第2期141-144,共4页
Journal of the Fourth Military Medical University
