摘要
针刺治疗心血管疾病疗效已经得到临床和基础研究的证实,针刺调节自主神经系统是其关键机制之一。肾上腺素β受体作为心交感神经递质的主要靶受体,心交感神经通过该受体调节心脏的功能。本文从肾上腺素β受体信号通路及交感神经和迷走神经活动的平衡角度出发,对近几年针刺治疗心血管疾病的机制进行梳理,以期为针灸科学化提供参考资料。
Acupuncture therapy has been confirmed to be effective in treating cardiovascular diseases in clinical practice. Acupuncture-induced balance of the autonomic nervous system activities is one of its key mechanisms. In the present paper, the authors review progress of studies on acupuncture treatment of cardiovascular diseases from 1) regulating cardiac sympathetic-be- ta-adrenergic receptor activity and myocardial intracellular GTP-binding protein (Gs)-adenylylcyclase (AC)-cyclic adenosine monophosphate (cAMP)-protein kinase (PKA) signaling, and 2) balancing cardiac sympathetic and vagal nerve activities. Due to limited experimental conditions, in-depth studies about the mechanisms of acupuncture intervention underlying improvement of car- diovascular functions are relatively fewer up to now, Along with the further development of modern biology, the mechanism of acu- puncture intervention underlying regulation of cardiac function via autonomic nerve system will be revealed in detail.
出处
《针刺研究》
CAS
CSCD
北大核心
2014年第1期83-86,共4页
Acupuncture Research
基金
国家重点基础研究发展计划("973")资助(2011CB 505206)
国家自然科学基金资助(81202744
81373749)
中国中医科学院自主选题项目(ZZKF 06003)
江苏省高校自然科学研究计划项目资助(11KJB 360008)
江苏省特色优势学科资助项目
江苏省高校青蓝工程优秀科技创新团队资助项目
江苏省普通高校研究生科研创新计划项目
关键词
针刺
自主神经系统
心功能
肾上腺素β受体
心脏疾病
Acupuncture
Autonomic nervous system
Cardiac function
Beta-adrenergic receptors
Cardiovascu-lar disease