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联合应用HE4和ROMA诊断卵巢癌的研究进展 被引量:6

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摘要 卵巢癌的早期表现与卵巢良性病变的临床表现相似,导致卵巢癌确诊时,患者有可能已处于卵巢癌晚期。由于卵巢癌患者的治疗时机极易被延误,导致卵巢癌在各种女性肿瘤的病死率中高居第五位。卵巢癌的治疗技术已有一定程度的提高,但仍无法降低其病死率。目前临床主要通过血清 CA125检测和妇科超声检查诊断卵巢癌,但 CA125在灵敏度和特异度方面均存在一定局限性。多种恶性肿瘤(如子宫内膜癌、宫颈癌、肺癌等)及良性疾病(如肾衰、肝功能衰竭、渗出液、卵巢囊肿、子宫肌瘤、子宫内膜异位症等)均可导致血清 CA125水平升高。人附睾蛋白4(HE4)是具有卵巢癌早期诊断性能的血清标志物。本文对 H E4作为卵巢癌的肿瘤标志物的相关研究及进展进行了综述。
出处 《检验医学与临床》 CAS 2014年第4期518-519,共2页 Laboratory Medicine and Clinic
基金 国家自然科学基金资助项目(81171628)
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参考文献21

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二级参考文献8

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