摘要
目的：探讨孕21-三体综合征胎儿、孕18-三体综合征胎儿和孕健康胎儿孕妇早孕期血清促甲状腺激素（TSH）水平和游离β-人绒毛膜促性腺激素（β-hCG）之间的关系，评价TSH用于早孕期产前筛查的临床价值。方法分别比较26例孕21-三体综合征胎儿、19例孕18-三体综合征胎儿和6782例孕健康胎儿孕妇孕11～13周时的血清TSH和游离β-hCG水平。结果孕21-三体综合征胎儿孕妇血清 TSH 水平较低（0．72＆#177;0．31MoM），而孕18-三体综合征胎儿孕妇血清TSH水平较高（1．48＆#177;0．57 MoM）。孕健康胎儿孕妇血清TSH和游离β-hCG水平具有负相关性（r＝-0．214，P＜0．05），但在孕染色体非整倍体胎儿孕妇体内，二者无相关性（孕21-三体综合征胎儿孕妇：r＝-0．157，P＞0．05；孕18-三体综合征胎儿孕妇：r＝-0．176，P＞0．05）。结论早孕期筛查 TSH 并不能有效提高21-三体综合征胎儿和18-三体综合征胎儿的检出率。
Objective To explore the relationship between thyroid stimulating hormone （TSH）and freeβ-hu-man chorionic gonadotropin （β-hCG）in maternal serum of trisomy 2 1 ,trisomy 1 8 and euploid pregnancies at 1 1-1 3 weeks and evaluate the potential value of TSH in first-trimester prenatal screening.Methods Maternal serum levels of TSH and freeβ-hCG at 11-13 weeks in 26 cases of trisomy 21 and 19 cases of trisomy 18 pregnancies were com-pared with levels in 6 782 cases of unaffected pregnancies.Results The trisomy 21 pregnancies were with lower ma-ternal serum levels of TSH （0.72＆#177;0.31 MoM）and the trisomy 18 pregnancies were with higher maternal serum levels of TSH （1.48 ＆#177;0.57 MoM）.There were significant associations between TSH and freeβ-hCG in the unaf-fected pregnancies （r=-0.214,P＆lt;0.05）,but not in those with trisomy 21 （r=-0.157,P＆gt;0.05）or trisomy 18 （r=-0.176,P＆gt;0.05）.Conclusion Measurement of TSH could not improve the performance of screening for tri-somy 21 and trisomy 18.
出处
《检验医学与临床》
CAS
2014年第4期459-462,共4页
Laboratory Medicine and Clinic
