摘要
目的:通过对复发性自然流产患者进行相关血栓标志物的检测,试图筛选出具有特征性、靶向性的临床应用指标,用以明确复发性自然流产血栓前状态的临床诊断及治疗。方法:将1 497例自然流产患者按流产次数分为1、2、3次及以上,分别检测组织型纤溶酶原激活物(t-PA)、纤溶酶原活化物抑制因子-1(PAI-1)、纤溶酶原降解产物(FDP)、交联纤维蛋白降解产物(D-D)、纤溶酶原(PLG)含量、抗凝血酶-Ⅲ(AT-Ⅲ)含量、蛋白C(PC)活性、蛋白S(PS)活性等血栓性指标,用统计学原理界定其特征性和靶向性。结果:AT-Ⅲ、PAI-1对不良妊娠结局的影响差异具有统计学意义(P<0.05),而且随着流产次数的增加特征性明显差异具有统计学意义(P<0.05)。结论:抗凝血酶-Ⅲ、纤溶酶原活化物抑制因子-1可作为复发性自然流产血栓前状态的诊断依据,成为复发性自然流产的致病因素及早期干预目标。
Objective： To screen out characteristic and targeting clinical application markers to clarify clinical diagnosis and treat merit of prethrombotic state of recurrent spontaneous abortion by detecting relative thrombosis markers among patients with recurrent spontane- abortion. Methods： A total of 1 497 patients with recurrent spontaneous abortion were divided into different abortion times： one time, times, three times and more. The contents of t - PA, PAI- 1, FDP, D - D, PLG, AT - Ⅲ and activities of PC, PS were detected ; sta- theory was used to definite the feature and targeting. Results： There was statistically significant difference in the impact on adverse outcome between AT - Ⅲ and PAI- 1 （P 〈 0. 05 ）, and with the increase of times of abortion, there was statistically significanti in the characteristics （ P 〈 0. 05 ） . Conclusion ： AT - ]U and PAl - 1 can be used as diagnostic criteria of prethrombotic state of ntaneous abortion, which are pathological factors and early intervention goals of recurrent spontaneous abortion.
出处
《中国妇幼保健》
CAS
北大核心
2014年第7期1052-1054,共3页
Maternal and Child Health Care of China
基金
首都医学科学发展基金项目资助〔2005-SF-Ⅲ-102〕
关键词
复发性自然流产
血栓前状态
血栓标志物
Recurrent spontaneous abortion
Prethrombotic state
Thrombosis marker
