摘要
目的 探讨地佐辛超前镇痛对腹腔镜手术患者血清IL-6和P物质的影响.方法 82例行腹腔镜手术的患者按数字表法随机分为两组,观察组41例,对照组41例.观察组采用常规麻醉加用地佐辛超前镇痛,对照组采用常规麻醉.采用视觉模拟评分（VAS）进行镇痛评分,测定两组血清IL-6和P物质.结果 观察组术后2h、12 h、24h的VAS评分分别为（1.02±0.42）分、（2.19±0.87）分、（1.69 ＆#177;0.96）分,均小于对照组的（1.39±0.77）分、（3.08±1.15）分、（2.27±1.21）分（t=5.536 2、2.0644、3.756 4,均P＜0.05）.观察组手术前、后血清IL-6、P物质分别为（117.4±17.2） mg/L、（204.4±23.6） mg/L、（4.21±0.96）mg/L、（4.33±1.03） mg/L,对照组分别为（115.3±14.7） mg/L、（276.5±29.1） mg/L、（4.19±0.94） mg/L、（6.92±1.37） mg/L,两组术后血清IL-6、P物质均明显升高,与对照组比较,观察组术后升高程度小（t=3.7544、7.643 0,均P＜0.05）.结论 地佐辛超前镇痛可明显减少腹腔镜手术患者血清IL-6和P物质的表达.
Objective To explore dezocine preemptive analgesia in laparoscopic operation on serum interleukin-6（IL-6） and substance P.Methods 82 cases of laparoscopic operation were randomly divided into two groups,41 cases in the observation group,41 cases in the control group.Observation group was treated with routine anesthesia and analgesia with dezocine,the control group with routine anesthesia.Using visual analogue score （VAS） of pain scores,measured in the two groups of serum IL-6 and P material.Results The observation group after 2h,12h,24h VAS scores were （1.02 ±0.42）,（2.19 ±0.87）,（1.69 ±0.96） points,which were less than the control group （1.39±0.77）%,（3.08 ±1.15）%,（2.27± 1.21）points （t =5.536 2,2.064 4,3.756 4,all P 〈0.05）.The observation group before and after operation,serum IL-6,P material were （117.4 ±17.2） mg/L,（204.4 ±23.6） mg/L,（4.21 ±0.96） mg/L,（4.33± 1.03） mg/L,the control group were （115.3±14.7） mg/L,（276.5 ± 29.1） mg/L,（4.19 ±0.94） mg/L,（6.92 ± 1.37） mg/L,two groups of postoperative serum IL-6,substance P （t =3.754 4,7.643 0,all P 〈 0.05）.Increased significantly,compared with the control group,the patients in the observation group the extent of small elevated（t =3.7544,7.6430,all P 〈 0.05）.Conclusion Dezocine extended analgesia in patients undergoing laparoscopic surgery can significantly reduce serum IL-6 and substance P expression.
出处
《中国基层医药》
CAS
2014年第1期58-60,共3页
Chinese Journal of Primary Medicine and Pharmacy
