摘要
目的 研究枸杞子糖缀合物及其糖链对LDL氧化修饰的抑制作用。方法 在Cu2 +诱导的LDL氧化模型中测定了脂质过氧化产物硫代巴比妥酸反应物质 (TBARS)的含量及LDL在琼脂糖凝胶电泳上的迁移率以反映从枸杞子中分离、纯化得到的糖缀合物及糖链对LDL氧化修饰的抑制作用。结果 枸杞子糖缀合物及糖链抗LDL氧化的能力是不同的 ,其中LbGp5可明显的抑制LDL的氧化。结论 枸杞子糖缀合物具有抗LDL氧化作用 。
AIM To determine the effects of glycoconjugates and their glycans from Lycium barbarum L. on inhibiting low density lipoprotein (LDL) peroxidation. METHODS Using Cu 2+ induced oxidation as a model, the oxidative production of thiobarbituric acid reactive substances (TBARS) and the LDL electrophoresis migration on agarose gel were measured. RESULTS The effects of glycoconjugates and their glycans from Lycium barbarum L. on inhibiting LDL peroxidation were different, among them, glycoconjugate LbGp5 showed the best effect on inhibiting LDLperoxidation. CONCLUSION The glycoconjugates can inhibit LDL peroxidatin while their glycans showed no effects on inhibiting LDL peroxidation.
出处
《药学学报》
CAS
CSCD
北大核心
2001年第2期108-111,共4页
Acta Pharmaceutica Sinica
基金
国家攀登计划!(970 2 110 0 6 4 4)资助项目
