摘要
目的观察老年轻度认知功能障碍(MCI)与血清总同型半胱氨酸(tHcy)、血脂水平之间的关系。方法测定50例老年MCI患者(MIC组)和50例年龄相匹配的健康者(对照组)血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)及血清tHcy水平。结果 MCI组患者血清TC、TG、HDL、LDL的水平分别为(5.72±1.25)mmol/L、(1.90±0.31)mmol/L、(1.03±0.12)mmol/L、(3.97±1.02)mmol/L;对照组健康者相应指标分别为(4.27±1.04)mmol/L、(1.21±0.17)mmo/L、(1.34±0.25)mmol/L、(3.03±1.00)mmol/L。MCI组TC、LDL、TG均明显高于对照组,差异有统计学意义(P<0.05)。MCI组血清tHcy水平明显高于对照组(P<0.05)。血清Hcy、血脂对预测MCI具有价值(P<0.05)。Logistic多因素回归分析提示血浆Hcy、血脂是MCI的影响因素。结论 MCI患者存在明显的脂质代谢紊乱及高同型半胱氨酸血症,Hcy、TC、LDL、TG可能对MCI的发病有一定的影响,而HDL与MCI发病可能无关联。
Objective To investigate the relation between total homocysteine, blood lipid level and mild cognitive impairment （MCI）. Methods The serum levels of total cholesterol（TC）, triglyceride（TG）, high density lipoprotein （HDL）, low density lipo- protein （LDL） and total Homocysteine（tHcy） were measured in 206 MCI patients（MIC Group） and 325 age-matched normal con- trols（Conrol Group）. Results The serum levels of TC,TG, HDL and LDL in MCI Group were（5.72＋1.25）mmol/L, （1.90± 0.31）mmol/L, （1.03±0. 12）mmol/L, （3.97±1.02） mm/L respectively, while （4. 27±1.04）mmol/L, （1.21±0. 17） mmo/L, （1.34 ±0.25）mmol/L, （3.03 ± 1.00）mmol/L in Control Group. There was a significant difference in the serum levels of TC, LDL and TG between the 2 groups（P〈0.05）. ROC curve showed tHcy level was valuable predicting the occurrence of MIC patients（P 〈0.05）. Logistic regression analysis showed that TC,TG, HDL, LDL and tHcy were independent risk factors of mild cognitive im- pairment patients. Conclusion Metabolic disturbance of serum lipids,tHcy existed in patients with MCI. THcy,TC,LDL and TG may increase me risk for the onset of MCI,while HDL may not.
出处
《国际检验医学杂志》
CAS
2014年第4期426-427,共2页
International Journal of Laboratory Medicine
