摘要
目的 探讨肝硬化病人血、尿β2 微球蛋白升高的临床特点及与肾功能的关系。方法 5 6例肝硬化患者按Child分级标准分成 3组 ,用放免法测定患者血、尿 β2 微球蛋白。结果 肝硬化病人血 β2 微球蛋白较正常对照组明显升高 ,并且与肾小球滤过率下降有相关关系。尿 β2 微球蛋白明显升高 ,且与肝功能损害程度有相关关系。结论 大多数肝硬化患者血 β2 微球蛋白都升高 ,并且与肾小球滤过率下降有关。在肝硬化早期即有尿 β2 微球蛋白升高 ,并与肝功能损害程度有相关关系。尿β2 微球蛋白有助于及早判断肝硬化病人肾小管的损伤程度。
Objective To find out the characteristic and the relations between β 2 microglobin (β 2 MG) in serum and urine and liver function in cirrhosis.Methods Serum and urine β 2 MG level were detected in 56 patients with hepatocirrhosis by radioimmunoassay(RIA).56 patients were divided into three groups according to the Child pugh score.Results Serum β 2 MG level was higher in patients with cirrhosis than in control group,and serum β 2 MG level correlated with glomerular filtration rate decrease.Urine β 2 MG level showed significant increase in cirrhosis and correlated with liver function impairment.Conclusion Serum β 2 MG level increased in most cirrhosis patients which related glomerular filtration rate.Urine β 2 MG level had increased in the early phase of cirrhosis,and increased higher when the liver function decreased,which help us find out renal tubule damage in time.
出处
《哈尔滨医科大学学报》
CAS
2001年第1期34-36,共3页
Journal of Harbin Medical University
