摘要
目的探讨分化抗原簇蛋白133(CD133)表达与新辅助化疗(NAC)化学敏感性的关系。方法对51例原发性乳腺癌患者在NAC治疗前后分别采用免疫组化方法检测CD133表达,观察NAC治疗前后CD133的差异性。结果CD133与病理完全缓解率(pCR)存在明显相关性(P=0.023)。NAC治疗后临床完全缓解率及部分缓解率(cCR+cPR)达到82.4%(42/51),病理反应2级+3级达到54.9%,pCR 31.3%(16/51)。CD133表达与乳腺癌淋巴结转移有关(P=0.042);CD133(+)在pCR方面明显低于CD133(-)(P=0.035);病理1级者较2级或3级更易出现CD133(+)(P=0.002)。CD133(+)在NAC治疗后57.1%(20/41)高于NAC治疗前47.1%(24/51),NAC治疗前后均为CD133(-)与病理反应有效率(2级)呈正相关关系(P<0.001)。同样,经NAC治疗后,8例CD133(+)转为CD133(-),其与病理有效率亦呈正相关关系(P=0.019)。结论 CD133可以作为一种有效标志物来预测NAC治疗乳腺癌的化学敏感性。
Objective To identify CD133 expression by immunohistoehemical staining testing before and after neoadjuvant chemotherapy (NAC) treatment and to diseuss the relationship between chemical sensitivity of CD133 expression and NAC treatment. Methods To observe the difference of CD133 using method to detect CD133 expression with 51 primary breast cancer patients before and after NAC treatment, respeetively. Results CD133 is obviously relevant of pCR ( P = 0. 023 ). The rate of eCR + cPR reached 82.4% (42/51) after NAC treatment. The rate of pathological reaetion level 2 + 3 reaehed 54.9%, pCR31.3% ( 16/51 ). CD133 expression is associated with breast cancer lymph node metastasis ( P =0. 042). The PCR expression in CD133 ( + ) was lower than that of CD133 ( - ) ( P =0. 035 ). Pathologi- eal grade 1 is more likely to appear CD133 ( + ) compared with level 2 or level 3 ( P =0. 002). CD133 ( + ) was 57.1% (20/41) after NAC treatment, which was more than 47.1% (24/51 ) before the NAC treatment. CD133 ( - ) has a positive correlation with pathological reaction effi- eieney ( level 2) ( P 〈 O. 001 ). 8 eases with CD133 ( + ) translated into CD133 ( - ) , whieh also had a positively correlation with pathological efficient ( P = O. 019). Conclusion CD133 can serve as an effective marker to predict the NAC chemical sensitivity for breast cancer patient.
出处
《临床和实验医学杂志》
2014年第4期297-300,共4页
Journal of Clinical and Experimental Medicine
基金
河北省承德市科学技术研究与发展计划项目(编号:20122186)
关键词
乳腺癌
新辅助治疗
CD133
化学敏感性
Breast cancer
Neoadjuvant chemotherapy
CD133
Chemical sensitivity