摘要
目的探讨不同剂量瑞舒伐他汀钙治疗老年冠心病合并高脂血症的临床效果。方法将本院2010年3月~2013年6月收治的150例老年冠心病合并高脂血症患者,采用随机数字表法分为5 mg组、10 mg组和20 mg组,每组50例,3组患者分别给予5、10、20 mg的瑞舒伐他汀钙治疗,比较3组的疗效、治疗前后血脂水平及不良反应发生率。结果 5 mg组的总有效率为74.0%,10 mg组的总有效率为80.0%,20 mg组的总有效率为92.0%,3组比较差异有统计学意义（P〈0.05）;3组的TG、TC、LDL-C比较差异有统计学意义（P〈0.05）;3组的HDL-C、不良反应发生率比较差异无统计学意义（P〉0.05）。结论 20 mg瑞舒伐他汀钙治疗老年冠心病合并高脂血症的临床效果显著,且不良反应发生率低。
Objective To explore clinical effect of different doses of rosuvastatin calcium in the treatment of senile coronary heart disease combined with hyperlipidemia.Methods 150 cases of elderly patients with coronary heart disease combined with hyperlipidemia in our hospital from March 2010 to June 2013 were divided into 5 mg group,10 mg group and 20 mg group by the random number table method,50 cases in each group,three groups of patients was given with 5 mg,10 mg and 20 mg of rosuvastatin calcium respectively.Clinical effect,incidence rate of adverse reaction and lipid levels before and after treatment in three groups was compared respectively.Results Total effective rate was 74.0% in 5 mg group,total effective rate was 80.0% in 10 mg group,total effective rate was 92.0% in 20 mg group,with statistical difference（P0.05）.TG,TC and LDL-C of three groups was compared respectively,with statistical difference（P0.05）. HDL-C and incidence rate of adverse reaction in three groups was compared respectively,with no statistical difference（P0.05）.Conclusion The effect of 20 mg rosuvastatin calcium in the treatment of senile coronary heart disease combined with hyperlipidemia is remarkable and has low incidence rate of adverse reaction.
出处
《中国当代医药》
2014年第6期64-65,68,共3页
China Modern Medicine
关键词
瑞舒伐他汀钙
冠心病
高脂血症
Rosuvastatin calcium
Coronary heart disease
Hyperlipidemia
