摘要
目的研究木芙蓉有效组分 (MFR)抗非特异性炎症的药效学。 方法将 6 0只Wistar雄性大鼠随机分为木芙蓉有效组分MFR -A、-B、-C组 ,中药阳性对照组 (正清风痛宁 ) ,西药阳性对照组 (扶他林 ) ,和空白对照组共六组 (每组 10只 ) ,采用鹿角菜致肿实验 ,致炎前 1h口服灌胃 ,致炎后 1、3、5、7h观察大鼠的足爪容积变化 ,筛选出木芙蓉最有效组分 ;然后将木芙蓉最有效组分分为剂量高、中、低组 ,中药阳性对照组和溶剂组 (Tween - 80 ) ,采用蛋清致肿实验 ,观察致炎后 1、2、3、4、5h的足爪容积变化。 结果木芙蓉A、B、C三个有效组分都有不同程度的抑制肿胀作用 ,尤以C组分作用明显 ,C组分高剂量组抗炎消肿作用与空白对照组比较有显著差异 ,与中药阳性对照组具有相同作用。 结论木芙蓉叶有效组分C具有较好地抑制特异性炎症的肿胀作用。
Objective To assess the anti-inflammatory activity of the effective fractions of Hibiscus mutabilis L.(MFR). Methods Sixty male Wistar rats were randomly divided into 6 groups with 10 in each: MFR-A, -B, and -C groups, sinomonine positive control group, Voltaren positive control group, and blank control group. In carrigeenin inducing inflammation test, the medications were administrated 1h before inflammation occurred, and the claws of rats were measured after inflammation occurred 1, 3, 5 and 7h to direct the best MFR. Then, the best MFR were divided into high, middle, and low dose groups. In ovi albumen inducing inflammation test, comparison with sinomonine positive control group and solvent (Tween-80) group, the claws of rats were measured after inflammation occurred 1, 3, 5, and 7h. Results Three MFR groups had marked effects of anti-inflammation, especially in the MFR-C which had significant difference compared with blank control group and had same effects to sinomonine group. Conclusion The results indicate that the active fractions of Hibiscus mutabilis L. could suppress the non-specific inflammation.
出处
《上海第二医科大学学报》
CSCD
2001年第1期14-16,共3页
Acta Universitatis Medicinalis Secondae Shanghai
基金
上海市教委资助重点课题(93zd33)
关键词
木芙蓉
抗炎
有效组分
Hibiscus mutabilis L.
anti-inflammation
effective fraction
