摘要
目的研究大鼠尾部悬吊模拟失重对脑学习记忆能力的影响。方法在方形水迷宫实验中测量对照组、对照束缚组、对照尾吊组、束缚组和尾吊组小鼠学习期和测试期中的正确分数、错误次数和通过率 ;在跳台实验中测量对照 (CON)组、尾吊 1 (TS 1 )组、尾吊 2 (TS 2 )组小鼠的潜伏期和错误时间。结果学习期各组动物的上述各指标均无显著性差异 ;测试期尾吊组的正确分数及通过率较学习期末明显降低 ;跳台实验结果 :与尾吊 5h时相比 ,尾吊后训练的鼠尾吊 2d时的潜伏期和错误时间无明显改变。训练后再尾吊的鼠尾吊 2d时潜伏期和错误时间明显缩短 ,7d时反而延长 ,提示尾吊 5h时小鼠学习能力下降 ,而记忆能力并未受到影响 ,7d时记忆能力下降。结论急性尾吊使小鼠学习能力、学习质量下降 ,尾吊 7d及 1 2d空间记忆能力降低。
Objective To study the effects of simulated weightlessness on learning and memory capability of the brain. Method Accuracy fraction, error frequency and pass rate were observed among control, restrained control, tail suspended(TS) control, restrained, and tail suspended mice in square water maze tests. And latent period and error time were observed in control and 30° tail suspension mice in step down test. Result The indices did not change significantly during learning period. Accuracy fraction of tail suspended group was reduced significantly in the tests accompared with pretest values. In step down test,latent period and error time showed no difference between TS 5 h and 2 d in untrained mice, but shortened evidently after TS 2 d and prolonged after TS 7 d in trained mice,which suggested the degradation of learning and memory ability after TS 5 h and 2 d respectively. Conclusion Acute tail suspension depressed brain's learning ability and quality, while tail suspension of 7 d and 12 d impaired the spatial memory in mice.
出处
《航天医学与医学工程》
CAS
CSCD
2000年第4期244-248,共5页
Space Medicine & Medical Engineering
关键词
失重模拟
学习
记忆
脑功能
小鼠
尾部悬吊
weightlessness simulation
learning
memory
brain function
mice
