摘要
目的观察T2DM合并乙型肝炎肝硬化(HBLC)患者不同HbA1c水平的血清细胞因子的变化。方法选取T2DM合并HBLC患者65例,根据HbA1c水平分为血糖控制良好组及血糖控制欠佳组,检测两组血清IL-2、IL-4、IL-6、IL-8、IL-10、干扰素γ(INF-γ)及TNF-α水平。结果血糖控制良好组血清细胞因子IL-2、TNF-α[(42.7±20.5)pg/ml、(30.5±20.2)ng/ml]低于血糖控制欠佳组[(58.2±23.8)pg/ml、(43.5±33.7)ng/ml],血糖控制良好组IL-4、IL-6、IL-8水平[(3.2±1.1)、(7.1±3.7)、(58.3±50.8)pg/ml]高于血糖控制欠佳组[(1.1±0.5)、(3.0±1.3)、(35.5±17.6)pg/ml,P<0.05]。血清IL-8、INF-γ水平两组间差异无统计学意义(P>0.05)。结论 T2DM合并HBLC患者血糖控制良好组对比血糖控制欠佳组辅助性T细胞1和2(Th1/Th2)细胞因子差异明显,其意义有待进一步探究。
Objective To investigate the effect of HbAlc on serum cytokine levels in T2DM patients combined with HBV-liver cirrhosis. Methods Sixty five T2DM patients with liver cirrhosis were recruited and divided into good contral group （ HbA1 c〉6.5 %, n= 38） and poor contral group （ HbA1c≤6. 5 %, n=27）. The serum levels of IL2,IL-4,IL-6,IL-8,IL-10,INF 7 and TNF-α were tested. Results The serum levels of IL-2 and TNF-α were higher in good control group [（42.7 ± 20.5） pg/m[, （30.5 ± 20.2） ng/ml] than in poor control group [（58.2＋23.8）pg/ml, （43.5＋33.7）ng/ml]. The serum levels of IL4, IL6, IL-8 were lower in good control group [ （ 3.2 ± 1.1）, （ 7.1 ± 3.7）, （ 58. 3 ± 50.8） pg/ml] than in poor control group[（1. 1-0. 5）,（3. 0±1. 3）,（35.5±17.6）pg/ml,P〈0.05]. Conclusion Good control blood glucose status can halance the cytokine network in hepatitis B virus-related cirrhosis patients.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2014年第2期138-140,共3页
Chinese Journal of Diabetes
关键词
乙型肝炎病毒
肝硬化
糖尿病
2型
细胞因子
Hepatitis B virus, liver cirrhosis
Diabetes mellitus, type 2
Cytokine
