摘要
目的了解血清成纤维细胞生长因子19(FGF19)在不同糖耐量人群中的水平,探讨其与瘦素(LP)间的关系。方法纳入糖耐量正常(NGT)者30名,IGT及T2DM患者各30例。采用酶联免疫法检测空腹血清FGF19与LP水平,分析FGF19与LP及相关代谢指标的关系。结果与NGT组比较,IGT与T2DM组血清FGF19水平均降低[(391.84±63.46)vs(312.89±62.57)ng/L,(391.84±63.46)vs(256.12±61.66)ng/L,P<0.01],血清LP水平均升高[(6.13±1.12)vs(6.82±0.90)μg/L,(6.13±1.12)vs(8.31±1.35)μg/L,P<0.01]。T2DM组LP、HOMA-IR和WC是FGF19水平的独立相关因素。结论 FGF19水平降低可能是T2DM发生发展的一个促进因素。FGF19水平降低与IR、LP抵抗密切相关,有望为改善T2DM和肥胖起到一定作用。
Objective In order to explore the serum FGF19 level and its relationship with serum leptin （LIP） in individuals with different levels of glucose tolerance. Methods Ninety individuals of NGT, IGT and T2DM（n= 30, each） were involved. Serum FGF19 and LP levels were measured by ELISA. The relationship between FGF19 and LP or other relative metabolic parameters were evaluated. Results Compared with NGT group, serum FGF19 levels in IGT and T2DM groups were decreased [（391.84± 63.46）vs （312. 89＋62. 57） ng/L, （391.84＋63. 46）vs（256.12＋61.66） ng/L, P〈0. 011, serum LP levels were increased [ （6.13＋1.12）vs（6.82＋0. 90）μg/L, （6.13＋1.12） vs（8. 31 d= 1.35） μg/L,P〈0. 01]. LP, WC and HOMA-IR were the independent predictors of FGF19 levels in T2DM group. Conclusion Decreased level of FGF19 may contribute to the occurrence and development of T2DM. Decreased level of FGF19 is closely related to LP-resistance and HOMA-IR. FGF19 might be a treatment target in T2DM and obesity control.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2014年第2期107-110,共4页
Chinese Journal of Diabetes
关键词
糖耐量
糖尿病
2型
成纤维细胞生长因子19
瘦素
胰岛素抵抗
Glucose tolerana Diabetes mellitus, type 2 Fibroblast growth factor 19 Leptin（LP） Insulin resistance
