摘要
目的探讨不稳定型心绞痛患者微量白蛋白尿与主动脉僵硬度的相关性。方法筛选不稳定型心绞痛患者190例,入选患者分别检测24 h尿白蛋白定量、颈-股动脉脉搏波传导速度和颈动脉中膜厚度。根据24 h尿白蛋白定量检测结果将入选患者分为正常白蛋白尿组(NA组)和微量白蛋白尿组(MA组)。分析微量白蛋白尿与主动脉僵硬度之间的关系。结果 MA组颈-股动脉脉搏波传导速度较NA组显著升高[(11.87±2.13)m/s vs.(8.69±1.2)m/s,P=0.012];颈-股动脉脉搏波传导速度与微量白蛋白尿呈正相关(r=0.531,P=0.000);多元线性回归分析提示颈-股动脉脉搏波传导速度独立于空腹血糖(β=0.036,P=0.236)、收缩压(β=0.082,P=0.123)的影响,与微量白蛋白尿相关(β=0.213,P=0.035)。结论不稳定型心绞痛患者微量白蛋白尿与主动脉僵硬度之间显著相关。
Objective To explore the association between microalbuminuria and arterial stiffness in patients with unstable angina. Methods One hundred and ninety patients with unstable angina were enrolled. All patients under- went 24 h-urinary albumin excretion measurement. Carotid-femoral pulse wave velocity （cfPWV） and the intima-media thiekness（IMT） of carotid artery were examined. According to the 24 h-urinary albumin excretion, patients were divided into the normoal albuminuria group （NA group） and the microalbuminuria group （MA group）. The relationship between microalbuminuria and arterial stiffness were analyzed. Results cfPWV in the MA group was significantly higher than that of the NA group [（11.87±2.13）m/s vs. （8.69±1.2）m/s, P= 0.012], and cfPWV was positively correlated with microalbuminmia （r = 0.531,P = 0.000）. Multiple linear regression analysis showed that the cfPWV was independently related to microalbuminuria （/3 = 0.213, P = 0.035）. Conclusion In patients with unstable angina, increased arterial stiffness is associated with microalbuminuria.
出处
《北京医学》
CAS
2014年第2期88-91,共4页
Beijing Medical Journal
