摘要
目的:评价针刺治疗腹泻型肠易激综合征的临床疗效,并探讨其作用机制。方法:将57例患者随机分为两组,针刺组29例予针刺太冲、足三里及三阴交等穴,每日1次,每周5次;药物组28例予口服匹维溴铵(每次50mg,每日3次)及双歧杆菌乳杆菌三联活菌片(每次4片,每日3次)治疗,均4周为一疗程。治疗前、后采用酶联免疫吸附测定法(ELISA法)检测两组患者血清5-羟色胺水平。分别于治疗前、治疗1周后、治疗4周后及治疗结束3个月后观察临床症状积分变化。结果:针刺组与药物组均可显著降低患者血清5-羟色胺水平(P<0.01,P<0.05),两组比较,差异无统计学意义(P>0.05);针刺组能显著改善患者临床症状,在治疗1周后、4周后以及治疗后3个月,对症状积分的改善均优于药物组(P<0.01,P<0.05),其总有效率为89.66%(26/29),亦优于药物组的67.85%(19/28,P<0.05)。结论:针刺治疗腹泻型肠易激综合征疗效优于药物治疗,其作用机制可能是针刺治疗可降低患者内脏敏感性,改善肠动力紊乱状况,调节脑-肠互动作用失衡状态。
Objective To evaluate the clinical efficacy of acupuncture for treatment of diarrhea-predominant irritable bowel syndrome and discuss its action mechanism. Methods Fifty-seven cases were randomly divided into two groups. The acupuncture group （29 cases） was treated with acupuncture at Taichong （LR 3）, Zusanli （ST 36） and Sanyinjiao （SP 6） etc. , once a day and 5 times per week. The medication group （28 cases） was trea- ted with oral administration of pinaverium （50 mg each time, 3 times a day） and live combined bifidobacterium and lactobacillus tablet （4 tablets each time, 3 times a day）. Four weeks were taken as a treatment course in both groups. Before and after treatment ELISA method was applied to measure the level of serum 5-HT of the patients in two groups. The scores of clinical symptoms were observed before treatment, after one and four weeks of treatment and 3 months after treatment, respectively. Results The level of serum 5-HT was significantly reduced in the acupuncture group and medication group （P〈0. 01, P〈0.05）, which had no statistical difference between two groups （P〈0.05）. Compared with the medication group, the scores of clinical symptoms were obviously improved in the acupuncture group after one and four weeks of treatment and 3 months after treatment （P〈0.01, P〈0.05）. The total effective rate was 89.66 ~ （26/29） in the acupuncture group, which was superior to 67.85 （19/28） in the medication group （P〈0.05）. Conclusion The efficacy of acupuncture is superior to that of medicine in the treatment of diarrhea-predominant irritable bowel syndrome. The acupuncture treatment could reduce the visceral sensitivity, improve the intestinal motility and regulate the imbalance of brain-intestine interactive function.
出处
《中国针灸》
CAS
CSCD
北大核心
2014年第2期135-138,共4页
Chinese Acupuncture & Moxibustion
基金
江苏省六大高峰人才项目:2009039
江苏省中医药领军人才项目:LJ 200905
关键词
腹泻型肠易激综合征
针刺疗法
5-羟色胺
diarrhea-predominant irritable bowel syndrome
acupuncture therapy
5-hydroxytryptamine
