摘要
真菌感染的发病率在全球范围内不断上升。随着抗真菌药物的广泛使用,耐药现象日益突出,然而临床上行之有效而且安全的抗真菌药物数量却捉襟见肘。因此寻找新的抗真菌药物是目前的一个热点研究方向。舍曲林是一种选择性5-羟色胺再摄取抑制剂,临床上常用于抑郁症、强迫症及经期综合症等的治疗。10多年前,有学者发现其对念珠菌及曲霉有一定的抑制作用,并对舍曲林的抗真菌机制进行了初步探讨。本文就舍曲林的抗真菌作用进行综述。
The incidence of fungal infections is rising worldwide.Along with the widespread use of antifungal agents,drug resistance is becoming more prominent.However,effective and safe antifungal agents are very scarce in clinics.Therefore,looking for new antifungal agents is a hot focus of researching works at present.Sertraline is a selective 5-serotonin reuptake inhibitors,commonly used in depression,obsessive-compulsive disorder,premenstrual syndrome,and so on.Ten years ago,a few of scholars found that sertraline has a certain inhibitory effect on the vitality of Candida and Aspergillus,and carried on the preliminary discussion about the antifungal mechanism.According to collecting and reading literature at home and abroad,this paper summarize the antifungal effects of sertraline.
出处
《中国真菌学杂志》
CSCD
2013年第6期378-380,384,共4页
Chinese Journal of Mycology
基金
兰州大学第二医院研究所室建设项目(2012-13)
关键词
舍曲林
真菌
抗真菌药物
sertraline
fungus
antifungal agents
