摘要
目的：观察术中单次静注小剂量右美托咪啶对妇科全麻手术患者镇静镇痛效果的的影响。方法选择择期在全麻下行妇科腹腔镜手术的患者42例，ASAⅠ～Ⅱ级，随机分为实验组（D）与对照组（C）组（n＝21）：D组麻醉诱导前10min静脉输注右美托咪定1μg/kg；C组以0．9％生理盐水替代，于麻醉诱导前10min静脉输注。观察并记录两组患者诱导前（基线）、研究药物输注结束后、插管前、气管插管时、插管后10min，30min，60min，手术结束时的BIS，MAP和HR以及插管后10min，30min，60min时呼气末七氟醚浓度及手术结束后七氟醚的总用量。观察和记录手术结束后患者呼之睁眼时间（t）及清醒拔管时间（t1）；记录术中及术后苏醒期不良反应的发生情况。结果与对照组相比，研究药物注射完毕后实验组的BIS值明显降低（P＜0．05）。手术结束后实验组七氟醚的总用量明显减少（P＜0．05）。与诱导前相比对照组患者插管时的MAP和HR明显升高（P＜0．05），但实验组无明显变化。麻醉维持期间，实验组患者的HR及七氟醚的呼气末浓度较对照组降低（P ＜0．05），但MAP无明显差异。结论右美托咪定1μg/kg静脉输注用于妇科全身麻醉手术患者安全、经济、有效，可减少麻醉药用量，维持血流动力学的稳定，不影响苏醒质量。
Objective To observe the anesthetic effects of intravenous injection of small dose of dexmedetomidine used in anes -thesia gynecological operation .Methods Forty-two patients,meeting gynecological laparoscopic operation in general anesthesia （ASA gradeⅠ~Ⅱ） were chosen and randomly divided into experimental group （D） and control group（group C）（n=21）：Group D accepted intrave-nous infusion of dexmedetomidine in 1μg/kg 10 minutes before the induction of anesthesia ,and Group C accepted 0.9% saline.BIS,MAP and HR were observed and recorded before induction （baseline）,after study drug infusion,before intubation,tracheal intubation,intubation af-ter 10min,30min,60min and the end of surgery .End-tidal sevoflurane concentration was observed and recorded 10min,30min,60min after in-tubation.The goggle time（T） and extubation time（T1） after the operation were observed and recorded .The recovery period of adverse reac-tions occurred during and after operation were recorded .Results Compared with the control group ,the study drug after injection in experi-mental group,BIS in experimental group decreased evidently （P〈0.05）.After the operation,the total amount of sevoflurane in the experimen-tal group significantly reduced（P〈0.05）.Compared with the prior to the induction of experimental group in patients ,MAP and HR were sig-nificantly increased（P〈0.05）,but the experimental group had no obvious change .The experimental group of patients with few adverse reac-tions.Conclusion Dexmedetomidine,used in 1μg/kg for patients under gynecological general anesthesia operation is safe ,economic,effec-tive.It can reduce the dosage of narcotic ,maintain hemodynamic stability ,improve awakening quality .
出处
《潍坊医学院学报》
2013年第6期471-473,共3页
Acta Academiae Medicinae Weifang
