摘要
目的：研究不同年龄组Tg-SwDI小鼠与同龄野生型（WT）小鼠筑巢行为的差异。方法：将小鼠按基因（Tg—SwDI和WT）和年龄（2～4月龄、10～12月龄、18～20月龄）分为6组，利用固有筑巢材料在群养小鼠家笼中进行集体筑巢行为实验，之后利用纸巾进行个体筑巢实验。结果：基因（F1.31=37．03，P〈0．0001）和年龄因素（F2,31=3．88，P〈0．05）对群体筑巢评分均有影响。Tg-SwDI小鼠与WT小鼠相比，各年龄组均有群体筑巢功能的下降。在个体筑巢实验中，2～4月龄和10～12月龄Tg-SwDI小鼠的个体筑巢功能下降不明显，18-20月龄组有显著变化。方差分析提示显著的基因（F1．135=23．64，P〈0．0001）和年龄（F2,135=15．46，P〈0．0001）影响。结论：Tg-SwDI小鼠可较早出现集体筑巢行为受损，可能反映其早期社交行为改变，与执行功能相关的个体筑巢行为较晚才出现明显下降。
Objective：To investigate the differences in the nesting behaviour between Tg-SwDI transgenic mice and wild-type （WT） mice. Methods： Transgenic Tg-SwDI （Tg） and wild-type （WT） mice have been studied to observe their group nest-building behaviors with chip shavings and individual nest-building behaviors with paper towels. Results： The genotype （FI,31=37.03 ,P〈0.0001 ）and age（F2,31=3.88 ,P〈0.05）had effect on the group nest construction, and the same on the individual nest-building. However, there were no significant differences between Tg and WT mice until 18-20 months. Conclusion： The Tg-SwDI transgenic mice showed a worse nest- ing compared to WT mice at the early ages when they were group-housed. Most individually housed mice in each group showed impaired nesting behavior in old age （18-20 months）.
出处
《神经损伤与功能重建》
2014年第1期1-5,共5页
Neural Injury and Functional Reconstruction
基金
国家自然科学基金(No.81271407)
