摘要
目的:观察胃复春片和复方田七胃痛片治疗难治性消化性溃疡(Pu)的临床疗效。方法:将80例难治性消化性溃疡患者门诊前后顺序分为观察组41例和对照组39例。对照组,雷贝拉唑钠肠溶片20 mg,早晚各服1次,疗程28 d;胶体果胶铋胶囊,150 mg/次,3次/d,疗程28 d;克拉霉素颗粒,0.5 g/次,3次/d,疗程14 d;阿莫西林胶囊,0.5 g/次,3次/d,14 d。疗程结束后以法莫替丁片,20 mg/次,1次/d,维持治疗4周。疗程共8周。观察组在对照组治疗的基础上加服胃复春片,4片/次,3次/d;复方田七胃痛片,4片/次,3次/d,均连续服用8周。记录治疗前主要症状积分,通过胃镜进行组织学再生黏膜成熟度评价及溃疡分期,计算幽门螺杆菌(HP)根除率。结果:观察组胃镜疗效总有效率为95.1%,对照组为76.9%,观察组优于对照组(P<0.05);观察组中医证候疗效总有效率为95.1%,对照组为71.8%,观察组优于对照组(P<0.05);治疗后观察组胃镜下愈合情况好于对照组(P<0.05);治疗后观察组再生黏膜组织学成熟度评价优于对照组(P<0.05);观察组胃脘痛、脘腹胀满、纳呆食少等各症状评分均低于对照组(P<0.01);对照组HP根除率为59.26%,观察组为76.67%,观察组高于对照组,但差异无统计学意义。结论:在西医常规3联疗法的基础上,采用胃复春片和复方田七胃痛片干预难治性消化性溃疡,能促进溃疡愈合,提高溃疡愈合质量,还能消除PU临床症状,提高疾病和中医证候疗效,近期疗效显著,值得临床试用。
Objective： The purpose is to observe the curative effect of Weifuchun tablet combined compound Tianqi Weitong tablet in intractable peptic ulcer （PU）. Method： Eighty cases of patients were randomly divided into control group （41 cases） and observation group （39 cases） according to the sequence of outpatient service, the patients in the control group took rabeprazole sodium enteric-coated Tablets, 20 mg/time, 2 times/day （morning and evening）, the treatment course was 28 days; Colloidal bismuth pectin capsules, 150 mg/time, 3 times/day, the treatment course for 28 days; Clarithromycin granule, 0.5 g/time, 3 times/day, treatment course for 14 days; Amoxicillin capsule, 0. 5 g/time, 3 times/day. After the treatment, treat patients with Famotidine tablets, 20 mg/time, 1 times/day, the treatment course continued 4 weeks. Based on the control group, patients in observation group increase with Weifuchun tablet, 4 pieces/time, 3 times/day; Weifuchun Tablet, 4 pieces/time, 3 times/day. The treatment course of two tablets were both 8 weeks. Record the main symptom integral before treatment. By gastroscope to evaluate the histologic regenerative mucosal maturity and ulcer stage. Calculate the eradication rate of helicobacter pylori （HP）. Result： After the treatment, thegastroscope curative effect rate of the observation group was 95.1%, superior to 76.9% of the control group, （P 〈0.05）. he traditional Chinese medicine syndrome rate of observation group was 95.1% , superior to 71.8% of the control group, （P 〈 0.05）. By chi-square test, after the treatment, the evaluation of regenerative mucosal histology rate of the observation group was superior to the control group （P 〈 0.05）. The scores of epigastric pain, abdominal fullness and distention, indigestion and loss of appetite of observation group was lower to the control group （P 〈 0.01 ）. the eradication rate for HP of the control group was 59.26% , the observation group was 76.67% , the observation group was higher than the
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第4期175-179,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
山西省卫生厅青年人才计划项目(20113019)
关键词
消化性溃疡
胃复春片
复方田七胃痛片
peptic ulcer
Weifuchun tablets
compound Tianqi Weitong tablet
