摘要
目的：探讨足量布地奈德联合特布他林雾化吸入治疗小儿毛细支气管炎的疗效及安全性。方法：选取沂水中心医院儿科2011年10月至20]2年6月收治的毛细支气管炎患儿220例，随机分为足量布地奈德组（A组）90例、常规剂量布地奈德组（B组）90例和对照组（c组）40例。三组患儿均采取常规综合治疗，A组每次给予布地奈德混悬液1mg、特布他林雾化液1．5-25mg空气压缩泵雾化吸入，3次／天，病情好转后改为每次布地奈德n5nag、特布他林每次1．5—2．5mg空气压缩泵雾化吸入，2次／天，疗程5～7d；B组采用布地奈德每次0．5mg、特布他林每次1．5—2．5mg空气压缩泵雾化吸入，2次／天，疗程5—7d；C组只采用常规综合治疗。观察三组患儿症状、体征改善时间、静脉应用糖皮质激素时间及住院时间，记录不良反应。结果：A组与c组比较，A组显效率、总有效率、咳嗽消失时间、喘憋消失时间、哮鸣音消失时间、静脉应用激素时间及住院时间均优于c组（P均〈O．01）；A组与B组比较，除总有效率两组比较差异无统计学意义外（P〉0．05），其他指标A组均优于B组，差异有统计学意义（P〈0．05或P〈O．01）；B组与c组比较，B组上述指标均优于c组（P〈O．05或P〈O．01）；三组均未发现明显不良反应。结论：足量布地奈德联合特布他林雾化吸入治疗毛细支气管炎疗效显著，且安全、方便。
Objective： To study the clinical effectiveness and safety of combined inhalation of terbutaline and enough budesonide for treatment of infantile bronchiolitis. Methods： Two hundreds and twenty patients with bronchiolitis were collected from the department of pediatrics from October 2011 to June 2012. All patients were randomly divided into an enough budesonide group A （n =90）, a conventional dose of budesonide group B （n=90） and a control group C （n=40）. The three groups were given the same comprehensive treatment. Group A were given atomizing inhalation of budesonide 1 mg and ferbutaline 1.5 ~ 2.5 mg , 3 times a day, while group B were respectively given budesonide 0.5 mg and ferbutaline 1.5 - 2.5 mg, 2 times a day. When clinical symptoms were recovered, group A were given atomizing inhalation of budesonide 0.5 mg and terbutaline 1.5 - 2.5 mg, 2 times a day. The average treatment course of the three groups was five to seven days. Group C were only given comprehensive treatment. The symptoms, intravenous application of hormone, length of hospital stay and incidence of adverse events of the three groups were observed. Results： Group A was better than group C in the obvious remission rate, total effective rate, the disappearance time of cough, breath shortness, wheezing, treatment course of intravenous hormone and length of hospital stay （P〈0. O1 ）. The total effective rate in group A and B had no significant difference （ P〉O. 05 ）, and other indicators of group A were superior to group B （ P〈0.05 or P〈0. O1 ）. The index of group B was better than group C （P〈0.05 or P〈0.01 ）. There were no side effects in the three groups. Conclusions： Inhalation of terbutaline combined with enough budesonside suspension is effective and safe for treatment of infantile bronchioles.
出处
《儿科药学杂志》
CAS
2014年第2期29-31,共3页
Journal of Pediatric Pharmacy
