摘要
干细胞具有多向分化的潜能,成年哺乳动物的生殖腺中存在生殖于细胞,在成体生殖腺中的生殖干细胞有精原干细胞,卵巢表皮细胞,极小胚胎样于细胞和卵巢干细胞。生殖干细胞具有干细胞的特性又具有分化为配子的功能。目前对于它的认识和应用仍然有限。本文诣在对生殖干细胞的生物学特性及其临床应用价值的新进展作一综述。
During mammalian development, migration, proliferation and survival of primordial germ cells can give rise to germ stem cells. There are evidences that stem cells also exist in adult gonad, and can maintain the renewal of germ cells and decelerate aging process. Therefore, germ stem cells play a pivotal role in rejuvenation of adult tissues as well as regeneration of damaged organs. Such cells have provided a potential resource for stem cell therapy and regenerative medicine.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2014年第1期39-43,共5页
Chinese Journal of Medical Genetics
基金
国家自然科学基金(81170611)
江苏省自然科学基金(BK2012601)
苏州市科技局基金(SYS201146)
关键词
生殖干细胞
精原干细胞
极小胚胎样干细胞
卵巢干细胞
Germ stem cell
Spermatogonial stem cell
Very small embryonic-like stem cell
Ovarian germ stem cell