1Goldberg MA, Dunning SP, Bunn HF. Regulation of the erythro- poietin gene : evidence that the oxygen sensor is a heme protein[J]. Science, 1988,242(4884) : 1412-1415. 被引量：1
2Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basie-helix-loop-helix-PAS heterodimer regulated by cellular 02 tension[J]. Proe Natl Acad Sci USA, 1995,92 (12) : 5510-5514. 被引量：1
4Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation[J]. Mol Cell Biol, 1992,12 (12) : 5447-5454. 被引量：1
5Otroek ZK, Hatoum HA, Awada AH, et al. Hypoxia-inducible factor in cancer angiogenesis:structure,regulation and clinical perspectives[J]. Crit Rev Oncol Hematol,2009,70 (2):93-102. 被引量：1
6Semenza GL. HIF-1 and mechanisms of hypoxia sensing[J]. Curr Opin Cell Biol,2001,13(2) : 167-171. 被引量：1
7Wang GL,Jiang BH ,Rue EA ,et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular 02 tension[J]. Proc Natl Acad Sci USA, 1995,92(12) :5510-5514. 被引量：1
8Semenza GL,Agani F, Booth G, et al. Structural and functional analysis of hypoxia-inducible factor 1 [J]. Kidney Int, 1997,51 (2) :553-555. 被引量：1
9Semenza GL. Hydroxylation of HIF-1 :oxygen sensing at the mole- cular leve[J]. Physiology (Bethesda), 2004,19 : 176-182. 被引量：1
10Dayan F, Monticelli M, Pouyss6gur J, et al. Gene regulation in response to graded hypoxia:the non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway[J]. J Theor Biol, 2009, 259(2) :304-316. 被引量：1
二级参考文献7
1Li J,Yen C,Liaw D,et al.PTEN,a putative protein tyrosine phosphatase gene mutated in human brain,breast,and prostate cancer Sdense,1997,275:1 943. 被引量：1
2Semem GL.Expression Of hypoXia-inducible factor l:mechanisms and consequences.Biochem Pharmacol,2000,59:47. 被引量：1
3Kurose K,Zhou XP,Araki T,et al.Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels,but not associated with p27 and cyclin D1 expression,in primary epithelial ovarian carcinomas.Am J Patho1,2001,158(6):2097-2106. 被引量：1
4Lee JW,Bae SH,Jeong JW,et al.Hypoxia-inducible factor(HIF-1) alpha its protein stability and biological functions[J].Exp MOl Med,2004,36(1):1-12. 被引量：1
5Shoshani T,Faeman A,Mett,et al.Identification of a novel hypoxia-inducible factor-1 responsive gene,R,RTP801,invo1ved in apoptosiS[J].Mol Cell Bi0l,2002,22(7):2283-2293. 被引量：1
6Imai T,Horiuchi A,Wang C,et al.HypoXia attenoates the expression of E-Cadherin via up-regulation of SNALL in ovarian carcinoma cells.Am J PATHOL,2003,163(4):1437-1447. 被引量：1
3Manolescu B, Oprea E, Busu C, et al. Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway [J]. Biochimie, 2009, 91(11-12): 1347-1358. 被引量：1
4Kimura S, Kitadai Y, Tanaka S, et al. Expression of hypoxia-induc- ible factor (HIF)-lalpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oe- sophageal squamous cell carcinoma [J]. Eur J Cancer, 2004, 40(12): 1904-1912. 被引量：1
5Befani C, Mylonis I, Gkotinakou IM, et al. Cobalt stimulates HIF-1-dependent But inhibits HIF-2-dependent gene expression in liver cancer cells [J]. Int J Biochem Cell Biol, 2013, 45(11): 2359-2368. 被引量：1
6Theodoropoulos VE, Lazaris AC, Sofras F, et al. Hypoxia-inducible factor-1 α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer [J]. Eur Urol, 2004, 46(2): 200-208. 被引量：1
7Melstrom LG, Salabat MR, Ding XZ, et al. Apigenin down-regulates the hypoxia response genes: HIF-lct, GLUT-l, and VEGF in human pancreatic cancer ceils [J]. J Surg Res, 2011,167(2): 173-181. 被引量：1
8Ord JJ, Agrawal S, Thamboo TP, et al. An investigation into the prognostic significance of necrosis and hypoxia in high grade and invasive bladder cancer [J]. J Urol, 2007, 178(2): 677-682. 被引量：1
9Bedessem B, Stephanou A. A mathematical model of HIF-la-medi- ated response to hypoxia on the G1/S transition [J]. Math Biosci, 2014, 248: 31-39. 被引量：1
10Streeter EH, Harris AL. Angiogenesis in bladder cancer-prognostic marker and target for future therapy . Surg Oncol, 2002, 11(1-2): 85-100. 被引量：1
